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Filtering by: Creator Nelson, A. Gene Remove constraint Creator: Nelson, A. Gene Committee Member Freitag, Michael Remove constraint Committee Member: Freitag, Michael Resource Type Dissertation Remove constraint Resource Type: Dissertation

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  • Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

    Creator:
    Kimbrel, Jeffrey A.
    Abstract:
    Symbiosis is the close and protracted interaction between organisms. The molecular interactions that occur during symbiosis are complex with multiple barriers that must be overcome. Many Gram-negative, host-associated bacteria use a type III secretion system to mediate associations with their eukaryotic hosts. This secretion system is a specialized apparatus for...
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    Dissertation
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    ........................................................................................... 282   Appendix V: GENE-counter: a computational pipeline for the analysis of RNA-Seq data for gene

  • Investigating Transcriptional Control of Specialized Gene Expression in Plants

    Creator:
    Fraser, Valerie N.
    Abstract:
    Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial to an organism, are not strictly necessary for survival. Plants use secondary metabolites to, among other things, attract pollinators, defend against biotic and abiotic stressors, and form symbioses. Natural products from plants have seen an...
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    Dissertation
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    determinants of tissue specific gene expression. A pair of predictive models were built using precise

  • Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

    Creator:
    Guo, Chunxiao
    Abstract:
    Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
    Resource Type:
    Dissertation
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    Transcriptional Regulation of the Human Cathelicidin Antimicrobial Peptide Gene by Chunxiao Guo A

  • Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

    Creator:
    Padgitt-Cobb, Lillian K.
    Abstract:
    Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
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    Dissertation
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    . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 A.3 Length Distribution of Contigs . . . . . . . . . . . . . . . . . . . . . 220 A.4 Gene and

  • Calpain 2 proteolysis regulates glioblastoma cell invasion

    Creator:
    Lal, Sangeet Kumar
    Abstract:
    Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...
    Resource Type:
    Dissertation
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    Glioblastoma Cell Invasion Abstract approved: Jeffrey A. Greenwood Glioblastoma

  • Analyses of noncanonical DNA structures

    Creator:
    Khuu, Patricia A.
    Abstract:
    The structural polymorphic nature of DNA has been long been recognized since the model of the right-handed B-DNA duplex proposed by James Watson and Francis Crick was accepted. Its malleability is thought to be critical in protein recognition and manipulation. In particular, it can form Holliday junctions, four-way DNA structural...
    Resource Type:
    Dissertation
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    Patricia A. Khuu for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on June

  • Influence of the Environment and Morphology on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

    Creator:
    Koch, Jack C.
    Abstract:
    Climate change and other anthropogenic impacts are threatening the existence of millions of species around the globe. On western continental boundaries, the large-scale secondary process of upwelling, which brings low pH, deoxygenated, high nutrient seawater to the surface, is compounded by climate change, that together could drive some species to...
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    Dissertation
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    each member of a temperate cnidarian-microbe symbiosis. From gene pathway to organism, the results of

  • Roles of homeodomain transcription factors during organogenesis

    Creator:
    Xu, Jun
    Abstract:
    The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
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    Dissertation
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    of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome

  • Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

    Creator:
    Creason, Allison L.
    Abstract:
    Plant pathogenic Rhodococcus species are persistent pathogens able to cause severe growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted by current models to synthesize a mixture of cytokinins that act to directly perturb the hosts' hormone balances, which results in abnormal...
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    Dissertation
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    pathogenic isolate that lacks the fas operon. However, this isolate contains a gene predicted to encode a

  • Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

    Creator:
    Garcia, Gloria R.
    Abstract:
    The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
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    Dissertation
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    ) located in the promoter of target genes (e.g. Cyp1a1, a cytochrome P450 gene) (Mulero-Navarro