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  • Influence of the Environment and Morphology on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

    Creator:
    Koch, Jack C.
    Abstract:
    Climate change and other anthropogenic impacts are threatening the existence of millions of species around the globe. On western continental boundaries, the large-scale secondary process of upwelling, which brings low pH, deoxygenated, high nutrient seawater to the surface, is compounded by climate change, that together could drive some species to...
    Resource Type:
    Dissertation
    Full Text:
    Integrative Biology presented on January 15, 2021. Title: Influence of the Environment and Morphology

  • The role of innate immunity in cnidarian-dinoflagellate symbiosis

    Creator:
    Poole, Angela Z.
    Abstract:
    Cnidarians, such as corals and sea anemones serve as hosts to a variety of organisms including symbiotic dinoflagellates, bacteria, virus, and apicomplexans. As corals are vital to the health and productivity of the reef ecosystem it is important to understand how these organisms interact with each component of the holobiont....
    Resource Type:
    Dissertation
    Full Text:
    Integrative Biology Dean of the Graduate School I understand

  • Genome-enabled discovery and characterization of type III effector-encoding genes of plant symbiotic bacteria

    Creator:
    Kimbrel, Jeffrey A.
    Abstract:
    Symbiosis is the close and protracted interaction between organisms. The molecular interactions that occur during symbiosis are complex with multiple barriers that must be overcome. Many Gram-negative, host-associated bacteria use a type III secretion system to mediate associations with their eukaryotic hosts. This secretion system is a specialized apparatus for...
    Resource Type:
    Dissertation
    Full Text:
    Biology presented on March 13, 2012. Title: Genome-enabled Discovery and Characterization of Type III

  • Characterization of the pathogenicity and phylogeny of members of the Rhodococcus genus

    Creator:
    Creason, Allison L.
    Abstract:
    Plant pathogenic Rhodococcus species are persistent pathogens able to cause severe growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted by current models to synthesize a mixture of cytokinins that act to directly perturb the hosts' hormone balances, which results in abnormal...
    Resource Type:
    Dissertation
    Full Text:
    OF Allison L. Creason for the degree of Doctor of Philosophy in Molecular and Cellular Biology

  • Generation of expression plasmids to study the function of the PRC2 subunit Suz12 in Fusarium graminearum

    Creator:
    Park, Catherine
    Abstract:
    The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...
    Resource Type:
    Honors College Thesis
    Full Text:
    without the 30-Nm Fiber.” Current Opinion in Cell Biology, Cell Nucleus, 58 (June 1, 2019): 95–104. (15

  • Prostate cancer prevention with broccoli : from cellular to human studies

    Creator:
    Clarke, John D.
    Abstract:
    Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
    Resource Type:
    Dissertation
    Full Text:
    for the Doctor of Philosophy in Molecular and Cellular Biology presented on April 28, 2011. Title

  • Investigating Transcriptional Control of Specialized Gene Expression in Plants

    Creator:
    Fraser, Valerie N.
    Abstract:
    Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial to an organism, are not strictly necessary for survival. Plants use secondary metabolites to, among other things, attract pollinators, defend against biotic and abiotic stressors, and form symbioses. Natural products from plants have seen an...
    Resource Type:
    Dissertation
    Full Text:
    . Fraser for the degree of Doctor of Philosophy in Molecular and Cellular Biology presented on August 2

  • Transcriptomic analysis using high-throughput sequencing and DNA microarrays

    Creator:
    Fox, Samuel E.
    Abstract:
    Transcriptomics and gene expression profiling enables the elucidation of the genetic response of an organism to various environmental cues. Transcriptomics enables the deciphering of differences between two closely related organisms to the same environment and in contrast, enables the elucidation of genetic responses of the same organism to different environmental...
    Resource Type:
    Dissertation
    Full Text:
    DISSERTATION OF Samuel E. Fox for the degree of Doctor of Philosophy in Molecular and Cellular Biology

  • Chlamydiae Enhance Self-Antigen Presentation in a Mechanism that is Dependent on Biosynthesis of Lipooligosaccharide

    Creator:
    Cram, Erik D.
    Abstract:
    Chlamydia is a genus of obligate intracellular bacteria that undergo a unique, biphasic developmental cycle. The infectious and metabolically inert Elementary Bodies (EBs) begin the cycle of infection by attaching and invading a host cells. Once inside, the EBs differentiate into the metabolically active, dividing Reticulate Bodies (RBs) within their...
    Resource Type:
    Dissertation
    Full Text:
    degree of Doctor of Philosophy in Molecular and Cellular Biology presented on March 23, 2016. Title

  • An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

    Creator:
    Manchanda, Aayushi
    Abstract:
    Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
    Resource Type:
    Dissertation
    Full Text:
    for the degree of Doctor of Philosophy in Molecular and Cellular Biology presented on October 22