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Filtering by: Committee Member Kolluri, Siva Kumar Committee Member Freitag, Michael

Antimicrobial peptide regulation by small molecules in humans and other primates

Creator:

Sinnott, Brian D.

Abstract:

Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families of antimicrobial peptides have been studied in humans: cathelicidins and defensins. There is a single cathelicidin in humans...

Resource Type:

Masters Thesis
Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:

Haggard, Derik

Abstract:

There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...

Resource Type:

Dissertation

Full Text:

scientist: Nancy Kerkvliet, Michael Freitag, Siva Kolluri, David Hendrix, Kim Anderson, and Anna Harding
The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

Creator:

Kyrylkova, Kateryna

Abstract:

BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...

Resource Type:

Dissertation

Full Text:

confident and successful woman Dr. Michael Freitag, Dr. John Fowler, and Dr. Siva Kolluri, my committee