Index Catalog // ScholarsArchive@OSU

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Creator:: Garcia, Gloria R.
Abstract:: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Resource Type:: Dissertation

In vivo detoxification of acetic acid in Saccharomyces cerevisiae

Creator:: Ding, Jun
Abstract:: The studies described in this thesis were motivated by ongoing efforts to develop lignocellulosic biomass as an efficient and practical source of renewable energy. Enormous problems complicate these efforts to reduce reliance on greenhouse gas-generating fossil fuels. Simply obtaining the fermentable sugars available in the cellulose and hemicellulose components of...
Resource Type:: Dissertation
Full Text:: uncover new mechanisms. 1.9. References Almeida, B., Ohlmeier, S., Almeida, A. J., Madeo, F

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation

The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

Creator:: Kyrylkova, Kateryna
Abstract:: BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
Resource Type:: Dissertation
Full Text:: . 13 References Albin, R. L., Young, A. B. and Penney, J. B. (1989). The functional anatomy of

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:: Goodale, Britton C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
Resource Type:: Dissertation
Full Text:: et al. 1995; Schmidt et al. 1996; Lahvis et al. 2005). Because their development can be observed

Analyses of noncanonical DNA structures

Creator:: Khuu, Patricia A.
Abstract:: The structural polymorphic nature of DNA has been long been recognized since the model of the right-handed B-DNA duplex proposed by James Watson and Francis Crick was accepted. Its malleability is thought to be critical in protein recognition and manipulation. In particular, it can form Holliday junctions, four-way DNA structural...
Resource Type:: Dissertation
Full Text:: Published in J. Mol. Recognit. 2006; 19: 234–242 14 2.1 Introduction Homologous

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Creator:: Guo, Chunxiao
Abstract:: Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
Resource Type:: Dissertation

Influence of the Environment and Morphology on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

Creator:: Koch, Jack C.
Abstract:: Climate change and other anthropogenic impacts are threatening the existence of millions of species around the globe. On western continental boundaries, the large-scale secondary process of upwelling, which brings low pH, deoxygenated, high nutrient seawater to the surface, is compounded by climate change, that together could drive some species to...
Resource Type:: Dissertation

Roles of homeodomain transcription factors during organogenesis

Creator:: Xu, Jun
Abstract:: The spatial and temporal patterning of sequence specific transcription factors (SSTFs) contributes to cell type specification and organ formation during embryogenesis. Homeodomain transcription factors are evolutionally conserved among invertebrate and vertebrate animals. They are responsible for body segmentation and organogenesis. Lbx1 and Pitx2 both are homeodomain transcription factors contributing to...
Resource Type:: Dissertation
Full Text:: . Developmental biology 322:381-393. Campbell AL, Shih HP, Xu J, Gross MK, Kioussi C (2012) Regulation of

Identifying the Enzymes Responsible for Reduction of Doxorubicin to its Cardiotoxic Metabolite Doxorubicinol using a Novel Immunoclearing Approach

Creator:: Breysse, Daniel H.
Abstract:: Doxorubicin is a widely used cancer therapeutic, but its effectiveness is limited by cardiotoxic side effects. Evidence suggests cardiotoxicity is due not to doxorubicin, but rather its metabolite, doxorubicinol. Identification of the enzymes responsible for doxorubicinol formation is important in developing strategies to prevent cardiotoxicity. In this study, the contributions...
Resource Type:: Masters Thesis

ScholarsArchive@OSU

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

In vivo detoxification of acetic acid in Saccharomyces cerevisiae

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Analyses of noncanonical DNA structures

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Influence of the Environment and Morphology on Physiological and Genomic Homeostasis in a Temperate Cnidarian-microbe Symbiosis

Roles of homeodomain transcription factors during organogenesis

Identifying the Enzymes Responsible for Reduction of Doxorubicin to its Cardiotoxic Metabolite Doxorubicinol using a Novel Immunoclearing Approach

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