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Filtering by: Creator Doerr, Michael D. Remove constraint Creator: Doerr, Michael D. Committee Member Gable, Kevin Remove constraint Committee Member: Gable, Kevin Degree Field Chemistry Remove constraint Degree Field: Chemistry

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  • Himeradine A : synthetic efforts towards himeradine A and related natural products, a Michael reaction focused approach

    Creator:
    Collett, Nathan D.
    Abstract:
    Lycopodium alkaloids have generated enormous amounts of interest from the scientific community, both as synthetic targets and for their medicinal properties. Herein is described work towards a unifying approach to large segments of the Lycopodium family. An organocatalyzed intramolecular heteroatom Michael reaction method, for the construction of piperidine and piperizine...
    Resource Type:
    Dissertation
    Full Text:
    Related Natural Products, a Michael Reaction Focused Approach. AN ABSTRACT OF THE DISSERTATION OF

  • Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis

    Creator:
    Carlson, Erik
    Abstract:
    Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...
    Resource Type:
    Masters Thesis
    Full Text:
    Heteroatom Michael Addition NH O N OH Cbz Cbz H 2.362.31 1.27 (20 mol%) MeOH / DCE (1:1), -25°C 2 d

  • Graphite intercalation compounds containing fluoroanions

    Creator:
    Katinonkul, Watcharee
    Abstract:
    New chemical synthesis strategies have been investigated for the preparation of acceptor-type graphite intercalation compounds (GIC's) with fluoroanions in order to obtain new materials and to develop a better understanding of the synthetic approaches and properties of the products. New GIC's containing borate chelate anion such as bis(oxalato)borate, CxB[OC(O)C(O)O]₂•δF, are...
    Resource Type:
    Dissertation
    Full Text:
    approved: Michael M. Lerner New chemical synthesis strategies have been investigated for

  • Aryl acetylene substituent effects : the synthesis and application of biaryls

    Creator:
    Naffziger, Michael R.
    Abstract:
    The work described herein details the synthesis and application of biphenyls that probe the effects of hydrogen, Cl / Br, and methyl substituents on the aryl ring of the terminal acetylenic carbon. From this work, we successfully developed the rapid synthesis of phenyl acetylenes in 3-4 steps from inexpensive commercially...
    Resource Type:
    Masters Thesis
    Full Text:
    AN ABSTRACT OF THE THESIS OF Michael R. Naffziger

  • Synthesis of furanoeremophilane sesquiterpenoids

    Creator:
    Shanmugham, Meenakshi Sundaram
    Abstract:
    Two approaches to the tricyclic core of the furanoeremophilane sesquiterpenoids are described. The first approach entails a projected Diels-Alder/retro Diels-Alder reaction of an acetylenic oxazole 64. Construction of the pivotal aldehyde 67 commenced from ketone 68. The acetyenic moiety was then introduced via a Felkin-Ahn addition of lithiopropyne to aldehyde...
    Resource Type:
    Dissertation
    Full Text:
    FURANOEREMOPHILANE SESQUITERPENOIDS Abstract approved: James D. White Two approaches to the tricyclic core of the

  • Atropisomeric 8,8'-biquinolyl derivatives : synthesis, properties and applications

    Creator:
    Milicevic, Selena D.
    Abstract:
    7,7'-Dihydroxy-8,8'-biquinolyl (azaBINOL) was prepared from 7-hydroxyquinoline via N,N-dimethyl O-quinol-7-yl carbamate by directed ortho-metallation followed by FeCl₃-mediated oxidative coupling of the 8-lithioquinoline intermediate. Saponification of the resulting dicarbamate provided crystalline (±)-azaBINOL in 56% overall yield. 6,6'-Bis(dimethylaminocarbonyl)-7,7'-dihydroxy-8,8´-biquinolyl was prepared from the same dicarbamate by a double anionic-Fries rearrangement in 43% yield. 7,7'-Bis(diethylamino-carbonyloxy)-6,6'-diiodo-8,8´-biquinolyl...
    Resource Type:
    Dissertation
    Full Text:
    DISSERTATION OF Selena D. Milicevic for the degree of Doctor of Philosophy in Chemistry presented on

  • Studies toward the total synthesis of azaspiracid-1

    Creator:
    Kuiper, Damien L.
    Abstract:
    Azaspiracid has generated an enormous amount of scientific interest in the fourteen years since its initial discovery. The structure contains a 6,5,6 bis-spiroketal, a [3.3.1] bicyclic ketal and a 6,5-spiroaminal linkage as key moieties. With 9 rings, 20 stereocenters and three alkenes, the azaspiracid immediately attracted the interest of the...
    Resource Type:
    Dissertation
    Full Text:
    Heteroatom Michael Approach to the FGHI ring sysem….…………...……………. 11 1.9: Nicolaou!s Approach to the FGHI

  • Proteomic approach to the analysis of DNA-binding proteins using mass spectrometry

    Creator:
    Stapels, Martha Degen
    Abstract:
    In proteomic studies, separate experimental protocols have been necessary to identify proteins, determine their function, and predict their three-dimensional structure. In this study, a function-based separation of proteins was conceived to fractionate proteins prior to enzymatic digestion. In the initial demonstration of this technique, a DNA substrate was used to...
    Resource Type:
    Dissertation
    Full Text:
    academic committee: Dr. Michael Schuyler, Dr. James Ingle, Dr. Kevin Gable, and Dr. George Pearson. I

  • Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

    Creator:
    Juniku, Rajan B.
    Abstract:
    Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: _____________________________________________________ James D. White Part I

  • Removal of Radioactive Strontium, Iodine, and Uranium from Contaminated Groundwater : Sorption Processes and Properties

    Creator:
    Leonard, Mary E.
    Abstract:
    Iodine-129 is a key risk driver at sites where nuclear materials have been fabricated or processed, and it is a predominant isotope of concern in long-term waste storage strategies. I-129 exists primarily as iodate in the subsurface at the Hanford Site in south-central Washington State. Between 15 and 40% of...
    Resource Type:
    Dissertation
    Full Text:
    coefficient, D, is the ratio of the concentration of a given substance in one phase to its concentration in