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Filtering by: Alternative title ssim Fishery research report no. 5 Remove constraint Alternative title ssim: Fishery research report no. 5 Committee Member Gable, Kevin Remove constraint Committee Member: Gable, Kevin Degree Field Chemistry Remove constraint Degree Field: Chemistry

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  • Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis

    Creator:
    Carlson, Erik
    Abstract:
    Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...
    Resource Type:
    Masters Thesis
    Full Text:
    . Homopipecolic acid was synthesized in 7 steps and 28% yield from commercially available 1-bromo-5-hexene

  • Catalytic desymmetrization of D₂d̳-symmertic proprochiral tetrasubstituted biphenyl compounds: a novel approach to the synthesis of axially chiral C₂-symmetric molecules

    Creator:
    Gunderson, Jeremey Tyson
    Abstract:
    Many D2d-symmetric 2,2',6,6'-tetrasubstituted biphenyls are readily prepared via net oxidative dimerization of appropriate 1,3-disubstituted benzenes. Conversion of such proprochiral compounds to useful C2-symmetric chiral biphenyls requires formal replacement of two substituents on opposing aryl ring units with alternate groups. This under exploited desymmetrization tactic has been demonstrated for the generation...
    Resource Type:
    Masters Thesis
    Full Text:
    of two groups X by two groups Y. The initial "substitution" event, 2 to 5, presents no issue of

  • Stereoselective synthesis & application of enantioenriched main group α-haloalkyl organometal reagents

    Creator:
    Emerson, Christopher R.
    Abstract:
    Sulfoxide-ligand exchange (SLE) and asymmetric halogen-metal exchange (AHME) processes were separately examined for the enantioselective synthesis of functionalized alpha-haloalkylmetal (carbenoid) reagents. Carbenoids derived from SLE were used to effect stereospecific reagent-controlled homologation (StReCH) of boronic esters and those generated via AHME were engaged in Darzens-type chemistry with aldehydes. Abstract for...
    Resource Type:
    Dissertation
    Full Text:
    -/-")%#-$)(.#0+5/)-+6$%72++ !89/'%/':,'+;$#/<#-"&?+ + 1@&"$/("+/22$%*#0A+ + B/7'+>?+C

  • Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

    Creator:
    Juniku, Rajan B.
    Abstract:
    Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine...
    Resource Type:
    Dissertation
    Full Text:
    Rajan Juniku for the degree of Doctor of Philosophy in Chemistry presented June 5, 2012. Title

  • Aryl acetylene substituent effects : the synthesis and application of biaryls

    Creator:
    Naffziger, Michael R.
    Abstract:
    The work described herein details the synthesis and application of biphenyls that probe the effects of hydrogen, Cl / Br, and methyl substituents on the aryl ring of the terminal acetylenic carbon. From this work, we successfully developed the rapid synthesis of phenyl acetylenes in 3-4 steps from inexpensive commercially...
    Resource Type:
    Masters Thesis
    Full Text:
    Richard, brother Jonathan, fiancé Kelsey Langan, and the rest of my family… there are no words available

  • Studies on naphthyridinomycin biosynthesis

    Creator:
    He, Weixuan
    Resource Type:
    Dissertation
    Full Text:
    dihydronaphthyridinomycin (5) respectively. Because 6 is readily oxidized to 2, it was characterized as its dimethyl

  • Atropisomeric 8,8'-biquinolyl derivatives : synthesis, properties and applications

    Creator:
    Milicevic, Selena D.
    Abstract:
    7,7'-Dihydroxy-8,8'-biquinolyl (azaBINOL) was prepared from 7-hydroxyquinoline via N,N-dimethyl O-quinol-7-yl carbamate by directed ortho-metallation followed by FeCl₃-mediated oxidative coupling of the 8-lithioquinoline intermediate. Saponification of the resulting dicarbamate provided crystalline (±)-azaBINOL in 56% overall yield. 6,6'-Bis(dimethylaminocarbonyl)-7,7'-dihydroxy-8,8´-biquinolyl was prepared from the same dicarbamate by a double anionic-Fries rearrangement in 43% yield. 7,7'-Bis(diethylamino-carbonyloxy)-6,6'-diiodo-8,8´-biquinolyl...
    Resource Type:
    Dissertation
    Full Text:
    activation (see Chapter 5). The research presented herein involved several interrelated sub-projects

  • Studies toward the synthesis of halichlorine and pinnaic acid

    Creator:
    Korf, Eric A.
    Abstract:
    Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered...
    Resource Type:
    Dissertation
    Full Text:
    ……..………..………..………..………..………..…...5 1.4. Synthetic studies……..………..………..………..………..………..………..…...6 1.4.1. Danishefsky’s total

  • Synthesis and catalytic applications of derivatives of 7,7'-dihydroxy-8,8'-biquinolyl (azaBINOL)

    Creator:
    Wang, Chao
    Abstract:
    The synthesis of axially chiral polyfunctional derivatives of 8,8'-biquinolyl was explored and the catalytic action of appropriate derivative types investigated in three separate processes: (1) the silylcyanation of carbonyl groups and imines, (2) alkylation of a glycine Schiff-base via phase transfer-catalysis, and (3) direct amide bond formation from simple amines...
    Resource Type:
    Dissertation
    Full Text:
    Heterocyclic biaryl compounds ……………………………………….. 2 1.2 The chemistry of 8,8 -́biquinolyls ……………………………………… 5

  • Studies toward the total synthesis of azaspiracid-1

    Creator:
    Kuiper, Damien L.
    Abstract:
    Azaspiracid has generated an enormous amount of scientific interest in the fourteen years since its initial discovery. The structure contains a 6,5,6 bis-spiroketal, a [3.3.1] bicyclic ketal and a 6,5-spiroaminal linkage as key moieties. With 9 rings, 20 stereocenters and three alkenes, the azaspiracid immediately attracted the interest of the...
    Resource Type:
    Dissertation
    Full Text:
    full five years before the first report of the progenitor was divulged. 5 Therein, James reported