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Filtering by: Creator Noga, Edward J. Committee Member Gable, Kevin Degree Field Chemistry

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Creator:

Zandkarimi, Fereshteh

Abstract:

State-of-the-art, high-resolution mass spectrometry techniques for acquisition of metabolomic and lipidomic data coupled with advanced computational methods provide new opportunities for interpreting large and complex datasets and comprehending the underlying biological processes of diseases. Both metabolomics and lipidomics strive to obtain comprehensive analyses of small molecules, i.e., metabolites and lipids,...

Resource Type:

Dissertation
Synthesis of furanoeremophilane sesquiterpenoids

Creator:

Shanmugham, Meenakshi Sundaram

Abstract:

Two approaches to the tricyclic core of the furanoeremophilane sesquiterpenoids are described. The first approach entails a projected Diels-Alder/retro Diels-Alder reaction of an acetylenic oxazole 64. Construction of the pivotal aldehyde 67 commenced from ketone 68. The acetyenic moiety was then introduced via a Felkin-Ahn addition of lithiopropyne to aldehyde...

Resource Type:

Dissertation

Full Text:

, 16, 965. 4. Arciniegas, A.; Perez-Castorena, A. L.; Parada, G.; Villasenor, J. I.; De Vivar, R