Index Catalog // ScholarsArchive@OSU

The 3.1 Ma to 100 ka Goat Rocks Volcanic Complex: Persistence and Evolution of Magmatism at a Long-Lived Major Andesite Locus on the Cascade Arc

Creator:: Wall, Kellie T.
Abstract:: The imposing andesite stratovolcano is the characteristic expression of subduction zone magmatism, posing hazards to coastal populations and bearing insight into deep Earth processes. On a map of a typical volcanic arc, one can easily distinguish the approximately linear alignment and regular spacing of these major edifices that stand out...
Resource Type:: Dissertation
Full Text:: encouragement. I thank my committee members Adam Kent, Anthony Koppers, Andrew Meigs, and Kevin Gable for

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Creator:: Riordan, Ruben
Abstract:: Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
Resource Type:: Dissertation
Full Text:: committee members Dr. Maria Clara Franco, Dr. Kathy Magnusson, Dr. Colin Johnson, and Dr. Kevin Gable

Hydrogenase in Azotobacter vinelandii : the role of the heme ligands in HoxZ

Creator:: Meek, Laura
Resource Type:: Dissertation
Full Text:: committee was particularly helpful to me and I would like to thank Chris Mathews, Kevin Gable, P. Shing Ho

Aryl acetylene substituent effects : the synthesis and application of biaryls

Creator:: Naffziger, Michael R.
Abstract:: The work described herein details the synthesis and application of biphenyls that probe the effects of hydrogen, Cl / Br, and methyl substituents on the aryl ring of the terminal acetylenic carbon. From this work, we successfully developed the rapid synthesis of phenyl acetylenes in 3-4 steps from inexpensive commercially...
Resource Type:: Masters Thesis
Full Text:: ..............................................trimethylsilyl TMSCl ..........................................trimethylsilyl chloride W

Synthesis of furanoeremophilane sesquiterpenoids

Creator:: Shanmugham, Meenakshi Sundaram
Abstract:: Two approaches to the tricyclic core of the furanoeremophilane sesquiterpenoids are described. The first approach entails a projected Diels-Alder/retro Diels-Alder reaction of an acetylenic oxazole 64. Construction of the pivotal aldehyde 67 commenced from ketone 68. The acetyenic moiety was then introduced via a Felkin-Ahn addition of lithiopropyne to aldehyde...
Resource Type:: Dissertation
Full Text:: invaluable and is greatly appreciated. I would also like to thank my committee members, Professor Kevin

Stereospecific Synthesis of Stereotriad Motifs and Alkenes Using Enantioenriched sp³-Hybridized Carbenoids

Creator:: Xun, Sun
Abstract:: Enantioenriched sp³-hybridized carbenoid reagents CR1R2MX (X = nucleofuge, M = electrofuge) of different types were investigated for the synthesis of polysubstituted alkyl chains by iterative stereospecific reagent-controlled homologation (StReCH) and for the stereospecific connective synthesis of alkenes by eliminative cross-coupling. In the first part, putative enantioenriched α-chloroalkyllithiums (CHRLiCl) were employed...
Resource Type:: Dissertation

Sources of Soil Carbon Loss from Soil Density Fractionation: Soluble Pools or Methodology?

Creator:: Gordon, Ester K.
Abstract:: Soil is the largest terrestrial store of carbon (C) making it a critical component of the global C cycle. To model global carbon budgets more accurately we need to understand dynamics and turnover of the many different functional soil C pools that exist in soil. Many different methods are used...
Resource Type:: Masters Thesis
Full Text:: . 18 Bibliography Baisden, W. T., Amundson, R., Cook, A. C., & Brenner, D. L. (2002). Turnover

Exploring Pactamycin Biosynthesis

Creator:: Roland, Jessica
Abstract:: Pactamycin, produced by the soil bacterium Streptomyces pactum, is a cytotoxic antibiotic that belongs to the aminocyclitol family of natural products. This antibiotic has shown various forms of biological activity, including antibacterial, antifungal, antimalarial, and antitumor activities. Despite its outstanding biological activity, the mode of formation of its pharmacophore (the...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Dr. Kevin Gable, representing Department of Chemistry

Analysis of the mechanism of sulfoxide-lithium exchange and the reactive intermediate in stereospecific reagent-controlled homologation (StReCH)

Creator:: Hoyt, Amanda
Abstract:: The stereospecific reagent-controlled homologation (StReCH) of boronic esters with enantioenriched carbenoid species generated in situ by the addition of organolithium initiators to stereodefined α-chloroalkyl aryl sulfoxides was previously reported. The reaction of an organolithium with an α-chloroalkyl aryl sulfoxide ostensibly generates an α-chloroalkyllithium via sulfoxide-lithium exchange; however, the true nature...
Resource Type:: Masters Thesis
Full Text:: = 1.11 g/mL, 30% w/w in H2O, MW = 34.01 g/mol, 147 mmol). The resulting mixture was allowed to warm to

Catalytic desymmetrization of D₂d̳-symmertic proprochiral tetrasubstituted biphenyl compounds: a novel approach to the synthesis of axially chiral C₂-symmetric molecules

Creator:: Gunderson, Jeremey Tyson
Abstract:: Many D2d-symmetric 2,2',6,6'-tetrasubstituted biphenyls are readily prepared via net oxidative dimerization of appropriate 1,3-disubstituted benzenes. Conversion of such proprochiral compounds to useful C2-symmetric chiral biphenyls requires formal replacement of two substituents on opposing aryl ring units with alternate groups. This under exploited desymmetrization tactic has been demonstrated for the generation...
Resource Type:: Masters Thesis
Full Text:: Drapela, Dr. Daniel Myles, Dr. Jeff Walker and Dr. Kevin Gable for believing in me and allowing me the

ScholarsArchive@OSU

The 3.1 Ma to 100 ka Goat Rocks Volcanic Complex: Persistence and Evolution of Magmatism at a Long-Lived Major Andesite Locus on the Cascade Arc

The Role of Cellular Senescence in the Development of Alzheimer's Disease

Hydrogenase in Azotobacter vinelandii : the role of the heme ligands in HoxZ

Aryl acetylene substituent effects : the synthesis and application of biaryls

Synthesis of furanoeremophilane sesquiterpenoids

Stereospecific Synthesis of Stereotriad Motifs and Alkenes Using Enantioenriched sp³-Hybridized Carbenoids

Sources of Soil Carbon Loss from Soil Density Fractionation: Soluble Pools or Methodology?

Exploring Pactamycin Biosynthesis

Analysis of the mechanism of sulfoxide-lithium exchange and the reactive intermediate in stereospecific reagent-controlled homologation (StReCH)

Catalytic desymmetrization of D₂d̳-symmertic proprochiral tetrasubstituted biphenyl compounds: a novel approach to the synthesis of axially chiral C₂-symmetric molecules

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