Index Catalog // ScholarsArchive@OSU

Stereocontrolled Synthesis of Allenes by Eliminative Cross-Coupling of Carbenoids

Creator:: Cao, Yang
Abstract:: The bimolecular reaction of two carbenoid species resulting in the formation of a carbon-carbon double bond (pi-system), referred to herein as carbenoid eliminative cross-coupling (CEXC), involves a series of three fundamental steps: (i) ate-complex formation (transmetalation), (ii) 1,2-metalate rearrangement, and (iii) beta-elimination. All three steps are stereospecific and so the...
Resource Type:: Dissertation
Full Text:: character ('Hoppe-type' C-lithiated N,N-diisopropyl O-alkyl carbamates) were combined with a variety of

Stereoselective synthesis & application of enantioenriched main group α-haloalkyl organometal reagents

Creator:: Emerson, Christopher R.
Abstract:: Sulfoxide-ligand exchange (SLE) and asymmetric halogen-metal exchange (AHME) processes were separately examined for the enantioselective synthesis of functionalized alpha-haloalkylmetal (carbenoid) reagents. Carbenoids derived from SLE were used to effect stereospecific reagent-controlled homologation (StReCH) of boronic esters and those generated via AHME were engaged in Darzens-type chemistry with aldehydes. Abstract for...
Resource Type:: Dissertation
Full Text:: -/-")%#-$)(.#0+5/)-+6$%72++ !89/'%/':,'+;$#/<#-"&?+ + 1@&"$/("+/22$%*#0A+ + B/7'+>?+C

Atropisomeric 8,8'-biquinolyl derivatives : synthesis, properties and applications

Creator:: Milicevic, Selena D.
Abstract:: 7,7'-Dihydroxy-8,8'-biquinolyl (azaBINOL) was prepared from 7-hydroxyquinoline via N,N-dimethyl O-quinol-7-yl carbamate by directed ortho-metallation followed by FeCl₃-mediated oxidative coupling of the 8-lithioquinoline intermediate. Saponification of the resulting dicarbamate provided crystalline (±)-azaBINOL in 56% overall yield. 6,6'-Bis(dimethylaminocarbonyl)-7,7'-dihydroxy-8,8´-biquinolyl was prepared from the same dicarbamate by a double anionic-Fries rearrangement in 43% yield. 7,7'-Bis(diethylamino-carbonyloxy)-6,6'-diiodo-8,8´-biquinolyl...
Resource Type:: Dissertation
Full Text:: at 23 °C in MeOH and CHCl3, respectively. A series of cyclic diethers were prepared from

Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

Creator:: Juniku, Rajan B.
Abstract:: Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine...
Resource Type:: Dissertation
Full Text:: functionalization of 245 was carried out for the purpose of assembling rings B and C of the complete neomangicol

Studies toward the total synthesis of sanglifehrin A

Creator:: Suttisintong, Khomson
Abstract:: Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
Resource Type:: Dissertation
Full Text:: cyclophilins A, B and C…..6 1.2 Activity of sanglifehrins A, B, C and D and cyclosporine A in the murine

Organic Phase Inter-Ligand and Metal-Ligand Speciation in TALSPEAK and ALSEP Solvent Extraction Systems

Creator:: Gullekson, Brian J.
Abstract:: Partitioning of trivalent actinides (in particular, americium and curium) from the fission produced light lanthanides is a major concern of used nuclear fuel reprocessing for the purposes of waste disposal. Several solvent extraction processes have been developed to address these chemically difficult separations. The historically employed TALSPEAK Process utilizes di-2-ethylhexyl...
Resource Type:: Dissertation
Full Text:: Strengths at 25.0 ± 0.1 °C and 1M Ionic Strength in Na+ Media…………………………….11 1.8. Lactic acid, the

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Creator:: Zandkarimi, Fereshteh
Abstract:: State-of-the-art, high-resolution mass spectrometry techniques for acquisition of metabolomic and lipidomic data coupled with advanced computational methods provide new opportunities for interpreting large and complex datasets and comprehending the underlying biological processes of diseases. Both metabolomics and lipidomics strive to obtain comprehensive analyses of small molecules, i.e., metabolites and lipids,...
Resource Type:: Dissertation
Full Text:: ....................................................................................................... 291 11 Appendix C

Hydrogenase in Azotobacter vinelandii : the role of the heme ligands in HoxZ

Creator:: Meek, Laura
Resource Type:: Dissertation
Full Text:: thank Don Armstrong, Lyle Brown, and Daryl Ehrensing for the many discussions on this project and

The 3.1 Ma to 100 ka Goat Rocks Volcanic Complex: Persistence and Evolution of Magmatism at a Long-Lived Major Andesite Locus on the Cascade Arc

Creator:: Wall, Kellie T.
Abstract:: The imposing andesite stratovolcano is the characteristic expression of subduction zone magmatism, posing hazards to coastal populations and bearing insight into deep Earth processes. On a map of a typical volcanic arc, one can easily distinguish the approximately linear alignment and regular spacing of these major edifices that stand out...
Resource Type:: Dissertation

ScholarsArchive@OSU

Stereocontrolled Synthesis of Allenes by Eliminative Cross-Coupling of Carbenoids

Stereoselective synthesis & application of enantioenriched main group α-haloalkyl organometal reagents

Atropisomeric 8,8'-biquinolyl derivatives : synthesis, properties and applications

Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

Studies toward the total synthesis of sanglifehrin A

Organic Phase Inter-Ligand and Metal-Ligand Speciation in TALSPEAK and ALSEP Solvent Extraction Systems

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Hydrogenase in Azotobacter vinelandii : the role of the heme ligands in HoxZ

The 3.1 Ma to 100 ka Goat Rocks Volcanic Complex: Persistence and Evolution of Magmatism at a Long-Lived Major Andesite Locus on the Cascade Arc

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