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Filtering by: Creator Thompson, Cynthia Sue Committee Member Gamble, Wil

Oligoribonucleotides directed at ribosomal protein binding sites as inhibitors of ribosomal small subunit assembly and as possible antibiotics

Creator:

Thompson, Cynthia Sue

Abstract:

The effects of oligoribonucleotides of identical or similar sequences to a ribosomal protein binding site, specifically S8, on prokaryotic 30S ribosomal assembly were investigated in Escherichia coli. The oligoribonucleotides were expected to bind to the target protein S8 and block its incorporation into the 30S subunit, resulting in a nonfunctional...

Resource Type:

Dissertation

Full Text:

THESIS OF Cynthia Sue Thompson for the degree of Doctor of Philosophy in Biochemistry and Biophysics