Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Subject Glutathione Committee Member Gombart, Adrian F. Subject Aging -- Molecular aspects

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:

Smith, Eric Jonathan

Abstract:

Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...

Resource Type:

Dissertation

Full Text:

Nrf2 consequentially attenuates synthesis and steady state levels of liver glutathione (GSH