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Filtering by: Creator Milovancev, M. Committee Member Gorman, Elena

The expression, function, and potential therapeutic targeting of serotonin receptors 1B and 2A in a canine osteosarcoma cell line

Creator:

Viall, Austin K.

Abstract:

The serotonergic system plays a significant regulatory role in osteoblast differentiation and proliferation. Serotonin (five-hydroxytryptamine or 5HT) may promote or inhibit osteoblast proliferation depending upon the serotonin receptor isoforms expressed by the cell. Classically, 5HT receptor 1B (5HTR1B) reduces osteoblast proliferation by inhibiting phosphorylation of the cAMP response element binding...

Resource Type:

Masters Thesis

Full Text:

5HT. Adapted from Pytliak M et al.25 4 5HT synthesized by neurons is stored within