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  • The aging endoplasmic reticulum

    Creator:
    Dixon, Brian M.
    Abstract:
    Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
    Resource Type:
    Dissertation
    Full Text:
    M. Hagen Hallmarks of aging include the accumulation of aberrant proteins and a lower

  • Biological characterization of coibamide A, a marine natural product from a Panamanian cyanobacterium

    Creator:
    Hau, Andrew M.
    Abstract:
    Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
    Resource Type:
    Dissertation
    Full Text:
    Jang and Jeffrey A. Greenwood. Syntheses and preparation of putative coibamide A and related

  • Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

    Creator:
    Rhoads, Timothy W.
    Abstract:
    Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...
    Resource Type:
    Dissertation
    Full Text:
    : Joseph S. Beckman Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by

  • Development of innovative applications for passive sampling devices : monitoring bioavailability, risk from exposure and environmental mixture toxicity

    Creator:
    Allan, Sarah E.
    Abstract:
    Chemicals must be bioavailable for there to be a potential for exposure and consequent risk to human or environmental health. Passive sampling devices (PSDs) are used to quantify the time-integrated concentration of bioavailable contaminants. We demonstrate that PSDs can be paired with the zebrafish developmental toxicity bioassay to produce site-specific,...
    Resource Type:
    Dissertation
    Full Text:
    .    Abstract approved:______________________________________________________            Kim A. Anderson

  • The detection of superoxide and implications for amyotrophic lateral sclerosis

    Creator:
    Robinson, Kristine M.
    Abstract:
    Mutations to superoxide dismutase were the first proven cause of Lou Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in the selective death of motor neurons that characterizes ALS. Nitric oxide competes effectively with superoxide dismutase for superoxide to form the powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...
    Resource Type:
    Dissertation
    Full Text:
    provide a stable source for in vitro experimentation. Second, the products from the peroxynitrite