Index Catalog // ScholarsArchive@OSU

Biological insertion of nanostructured germanium and titanium oxides into diatom biosilica

Creator:: Jeffryes, Clayton S.
Abstract:: There is significant interest in titanium oxide and germanium-silicon oxide nanocomposites for optoelectronic, photocatalytic, and solar cell applications. The ability of the marine diatom Pinnularia sp. to uptake soluble metal oxides from cell culture medium, and incorporate them into the micro- and nano-structure of their amorphous silica cell walls, called...
Resource Type:: Dissertation
Full Text:: Gregory L. Rorrer There is significant interest in titanium oxide and germanium-silicon oxide

Optimal control of an underactuated bipedal robot

Creator:: Jones, Mikhail S.
Abstract:: Bipedal robots represent a unique class of control problems that combine many of the most difficult elements of nonlinear control. These robots are typically designed to be mobile and as such have limited energy and actuator authority making efficiency a prime concern. Unlike wheeled robots, legged robots must transition between...
Resource Type:: Masters Thesis
Full Text:: ,p) + ∫ tf t0 L(x(t),u(t), t,p)dt, (2.1) subject to the first order differential equation

Microbial Electrolysis Cells for the Production of Hydrogen Gas : Evaluation of Internal Resistance and Design for Scale-Up

Creator:: Miller, Andrew G.
Abstract:: Modification of microbial electrolysis cells (MECs) by altering the sizes of the anode and the cathode, or their interaction with the liquid stream affects the performance of the MEC, but it remains difficult to quantify how much each change will contribute to the overall performance. Through this study, a method...
Resource Type:: Masters Thesis
Full Text:: , with a hydrogen (H2) production rate of 3.7 L/ L-liquid volume/day. Highest performance was

Chandler Loop Model for the Development of Dynamic Hemocompatibility Assays

Creator:: Hasbrook, AnneMarie V.
Abstract:: A common issue with extracorporeal medical devices is blood clotting due to bio-incompatibility. Systemic anticoagulants are often prescribed to mitigate the coagulation issues. However, such drugs can lead to further complications, for example hemorrhaging. One solution to improve the hemocompatibility of blood-contacting medical devices are biomaterials, such as slippery liquid...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adam Z. Higgins, Committee Member, representing Bioengineering

Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function

Creator:: Thierheimer, Marisa
Abstract:: Platelets undergo morphological changes essential to hemostasis upon activation at sites of vascular injury. The Rho GTPases Rac1, Cdc42, and RhoA drive these changes. Rho guanine nucleotide dissociation inhibitors (RhoGDIs) bind to the Rho GTPases to block the GDP from dissociating from the Rho GTPases, as well as anchoring the...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adam Higgins, Committee Member, representing the school of Chemical, Biological, and

Experimental study of subcooled water spray cooling using flow symmetric micro-structured surfaces

Creator:: Tulchinsky, Alex M.
Abstract:: Spray impingement cooling has been shown to be a leading candidate for future high heat flux cooling applications. In general, spray cooling curves consist of three heat flux regimes; single-phase, two-phase and critical heat flux (CHF). CHF is considered the design limit for almost all two-phase cooling applications, as a...
Resource Type:: Masters Thesis
Full Text:: . Sourabh Apte, and Dr. Adam Higgins, in particular Dr. Deborah Pence and Dr. James Liburdy for their

Hibernation Strategies to Improve Organ Preservation and Storage

Creator:: Engler, Maja T.
Abstract:: Looking to the natural world for insight into medical innovations is currently understudied and possibly underappreciated in the field of medicine. Natural environmental adaptations seen in wild animals can provide both inspiration and scientific realization for the future of human medicine. As humanity faces a global organ shortage crisis, research...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adam Z. Higgins, Committee Member, representing Chemical, Biological, and Environmental

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Creator:: Laschober, Nicole B.
Abstract:: Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
Resource Type:: Honors College Thesis
Full Text:: University _____________________________________________________________________ Adam Higgins

Extracorporeal Treatment of Hyperuricemia via Enzymatic Functionalized Microchannel Processing Platform (iCore): Experiment and Modeling

Creator:: Pantakitcharoenkul, Jaturavit
Abstract:: Hyperuricemia is the condition of excessive presence of plasma uric acid ≥ 6 mg/dl. Conventional clinical/hospital urate-lowering treatment includes the administration of non-steroid anti-inflammatory drugs or xanthine oxidase inhibitors. Numerous drawbacks can be observed from these conventional treatments. In patients with refractory gout symptoms and tumor lysis syndrome, recombinant uricase...
Resource Type:: Dissertation
Full Text:: much from both of you. I would like to show my appreciation to Dr. Adam Higgins for allowing me to

Machine learning approach to improve drug discovery in natural product extracts

Creator:: Heussner, Robert T.
Abstract:: Current natural product (NP) research is limited by its reliance on bioassay-guided fractionation to identify bioactive compounds in mixtures. Computational approaches may improve NP research by correlating mass spectra (MS) and nuclear magnetic resonance spectra (NMR) of bioactive mixtures to their bioactivity patterns. In this study, I use artificial neural...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adam Higgins, Committee Member, representing Chemical, Biological, and Environmental

Geometric Chatter Stability Index for Milling and Modeling of Chip Pulling Effect

Creator:: Maulimov, Mukhtar
Abstract:: Prediction and mitigation of chatter vibrations in machining operations and optimizing overall machining mechanics are crucial for achieving greater productivity and manufacturing efficiency. This thesis first explores effect of directional relationships on chatter stability in milling process. Based on the directional relationships, a geometry-based chatter stability index (CSI) is proposed...
Resource Type:: Masters Thesis
Full Text:: would like to thank Josiah Adam Breen for his assistance with the experimental setup that is used in

Ink and Substrate Compatibility for Electrochemical Sensing in Paper-based Devices

Creator:: Reid, Caitlin A.
Abstract:: Electrochemical sensing provides a quantitative alternative to colorimetric reactions within paper-based devices. The paper-based devices were fabricated by screen printing the conductive and reference inks onto porous substrates that were evaluated using cyclic voltammetry. Devices were evaluated based on the magnitude of the average anodic peak height, which correlates with...
Resource Type:: Honors College Thesis
Full Text:: Engineering _____________________________________________________________________ Adam Higgins

Probing the Biophysical interactions of Anti-Microbial Peptide WLBU2 Using Model Membrane Systems

Creator:: Golbek, Thaddeus W.
Abstract:: WLBU2 is an engineered cationic amphiphilic peptide that targets Gram-positive and Gram-negative bacteria, and envelopes endotoxin while avoiding other cell types. The exact mechanism of how WLBU2 targets, binds, and disrupts bacterial cell membranes is still not completely known. Thus, the overall goal of this investigation is to determine the...
Resource Type:: Masters Thesis
Full Text:: .; Burrows, L. L.; Deber, C. M. Basis for Selectivity of Cationic Antimicrobial Peptides for Bacterial

A Manufacturing Process Design for Producing a Membrane-based Energy Recovery Ventilator with High Aspect Ratio Support Ribs

Creator:: Kawula, Steven P.
Abstract:: Heating, ventilation, and air conditioning systems represent nearly half of building energy usage in the United States. Recent building regulations requiring increased air turnover within buildings will result in even greater air conditioning usage. To alleviate these concerns, membrane-based heat-and-moisture exchangers known as energy recovery ventilators have been developed to...
Resource Type:: Masters Thesis
Full Text:: Strength Test Error……………………….…130 Appendix L: Future Work…………………………………………………………..132

Precision Medicine for the Intervertebral Disc: Image Processing and Computational Modeling of Disc Degeneration to Inform Patient-Specific Therapies

Creator:: Ahrens, Sonia R.
Abstract:: The human intervertebral disc is a deceptively simple structure which plays an essential role in human movement. Even slight changes to the disc microenvironment can have far reaching consequences, particularly when these changes result in disc degeneration and herniation. Degeneration is increasingly tied to lower back pain; better understanding this...
Resource Type:: Masters Thesis

An experimental study on tensile properties of cellulose nanocrystal reinforced epoxy nanocomposite material

Creator:: Zeng, Jin
Abstract:: Epoxy resin is a thermosetting resin that is commonly used as composite matrix. Epoxy composite materials are well utilized in industries, such as aerospace, due to their good mechanical properties. Nano-scale filler reinforced polymer composite materials have been intensively researched in recent decades. Cellulose nanocrystals (CNXLs) are a type of...
Resource Type:: Masters Thesis
Full Text:: , Dr. William H. Warnes, and Dr. Adam Z. Higgins for agreeing to serve in my academic committee and

Binding of bacterial lipopolysaccharide by the cationic amphiphilic peptide WLBU2 at interfaces

Creator:: Ryder, Matthew P.
Abstract:: Passage of blood through a sorbent device for removal of bacteria and endotoxin by specific binding with immobilized, membrane-active, bactericidal peptides holds promise for treating severe blood infections. Peptide insertion in the target membrane and stable binding is desirable, while membrane disruption and release of degradation products to the circulating...
Resource Type:: Dissertation
Full Text:: my esteemed and venerable committee members, Dr. Adam Higgins, Dr. Jeff Nason, and Dr. Deborah

Biomechanical Modeling of Isometric Muscle-Tendon Force Generation Through Tendons Coupled in Parallel and a Passive Differential Mechanism

Creator:: Le, Anthony H.
Abstract:: There are at least fifteen types of upper extremity tendon transfer procedures for combined peripheral nerve injuries that involve re-routing a single donor muscle to multiple recipient tendons. As a result, force and movement across finger joints become coupled, resulting in limited grasping abilities. Quantification and modeling of the donor...
Resource Type:: Masters Thesis
Full Text:: academic career plans this year. Special thanks to Dr. Adam Higgins for introducing me to Ravi and his

Microfluidic Investigations of Capillary Flow and Surface Phenomena in Porous Polymeric Media for 3D Printing

Creator:: Donovan, Katrina J.
Abstract:: The advent of 3D Printing has invigorated research into metamaterials, synthetic composite material that produce properties generally not found in natural materials, requiring further studies into understanding the fundamental properties of these materials. This dissertation proposes a novel imaging technique to investigate the surface interactions occurring in an unsaturated packed...
Resource Type:: Dissertation

Modelling Thin Liquid Film Draining of Bubbles on Porous Media in Confined Geometry

Creator:: Bahm, Jared S.
Abstract:: The behavior of the thin liquid ﬁlm formed between a bubble and hydrophobic membrane is of high interest in applications where separating two-phase mixtures is beneﬁcial. One such application is in-situ vapor extraction heat sinks. In these systems, high heat transfer rates are accomplished by taking advantage of the high...
Resource Type:: Masters Thesis
Full Text:: B buoyancy CB Cassie-Baxter D departure e exit ext extraction G growth g gas i inlet l

Single Phase and Flow Boiling Heat Transfer and Flow Characterization in Microscale Pin Fin Heat Sinks

Creator:: Rasouli, Erfan
Abstract:: The ever increasing requirements for heat dissipation in various thermal management applications such as computer chip cooling and high power electronics have necessitated the need for novel thermal management techniques. Thermal management using heat sinks with microscale features is amongst the prominent techniques developed over the past two decades. In...
Resource Type:: Dissertation
Full Text:: Pence, Dr. Kendra Sharp, Dr. Sourabh Apte, and my GCR Dr. Adam Higgins for taking the time to review

Fabrication of Cost-effective Flexible Glucose Sensor for Continuous Glucose Monitoring

Creator:: Mullapudi, Sri Sai Kameswara
Abstract:: Diabetes is a pandemic that affects nearly 29.1 million Americans and the fourth leading cause of mortality in the US. Type 1 diabetes is a chronic condition which occurs due to little to no production of insulin by the pancreas. This form of diabetes requires constant monitoring of blood glucose...
Resource Type:: Masters Thesis
Full Text:: for each of the professors that I took classes from and Drs. Greg Herman, Larry Cheng, Adam Higgins

Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres

Creator:: Fry, Allyson Kaye
Abstract:: Contact of blood with the surfaces of synthetic materials is associated with spontaneous protein adsorption, initiating platelet aggregation, the coagulation cascade, and the eventual development of a stable clot. Current therapy to inhibit implant-induced thrombosis is life-long administration of systemic anticoagulants. An alternative to the systemic administration of anticoagulant drugs...
Resource Type:: Masters Thesis

Role of Alloying on the Thermal Stability of Duplex Stainless Steel

Creator:: Garfinkel, David
Abstract:: Duplex stainless steels (DSS) are an attractive potential material in nuclear power generation systems due to an excellent combination of corrosion resistance, strength, toughness, and affordability. Thermal embrittlement caused by phase instability in the temperature range of ~300-550°C severely limits the service temperature of DSS. The rate of embrittlement varies...
Resource Type:: Masters Thesis
Full Text:: Fei Teng and Ben Adam for providing me with assistance whenever it was needed. Finally, I would

Oxidation of Amorphous Metal Alloy Surfaces Studied Using Ambient Pressure X-Ray Photoelectron Spectroscopy

Creator:: Alzaga Elizondo, Pedro
Abstract:: Amorphous metal thin films (AMTFs) are of growing interest due to their unique mechanical properties and chemical stability. AMTFs have an advantage over polycrystalline metal films due to the lack of grain boundaries which gives AMTFs added durability and relatively smoother surfaces. For this reason, AMTFs have been investigated as...
Resource Type:: Masters Thesis

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

Creator:: Gómez Ramirez, Luis A.
Abstract:: Decline in cardiac pump function is a hallmark of aging where mitochondrial decay is an important underlying cause. Although certainly multifactorial in nature, both dysfunction of the machinery involved in the chemiosmotic process of energy transduction and lower capacity to maintain fatty acid-driven respiration are identified as intrinsic factors of...
Resource Type:: Dissertation
Full Text:: more generally results from cardiac decrements in L-carnitine levels. In order to clarify the role of

Technology to promote concept-based, active learning and enable education research

Creator:: Brooks, Bill J.
Abstract:: This dissertation centers on development of two web-based, in class learning tools, the AIChE Concept Warehouse (CW) and the Web-based Interactive Science and Engineering Learning Tool (WISE), and describes the investigation of student learning through their use. The intent of these tools is to promote deeper conceptual understanding in students...
Resource Type:: Dissertation
Full Text:: some funky figure formatting. In Chapter 3, Dr. Milo Koretsky and Dr. Adam Higgins contributed to the

Surface Characterization of Engineered Biomaterials

Creator:: Faase, Ryan A.
Abstract:: The work presented in this dissertation highlights the various techniques available to characterize the increasingly complex surfaces of engineered biomaterials. The methods used range from the simple measurement of a contact angle with a smartphone to a complex synchrotron technique like near edge x-ray absorption fine structure (NEXAFS) spectroscopy to...
Resource Type:: Dissertation
Full Text:: from the mean within the plane of the sample.42 𝑅𝑞 = 1 𝐿 ∫ 𝑍 2(𝑥)𝑑𝑥 𝐿 0 (2

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