Index Catalog // ScholarsArchive@OSU

Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function

Creator:: Thierheimer, Marisa
Abstract:: Platelets undergo morphological changes essential to hemostasis upon activation at sites of vascular injury. The Rho GTPases Rac1, Cdc42, and RhoA drive these changes. Rho guanine nucleotide dissociation inhibitors (RhoGDIs) bind to the Rho GTPases to block the GDP from dissociating from the Rho GTPases, as well as anchoring the...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adam Higgins, Committee Member, representing the school of Chemical, Biological, and

Experimental study of subcooled water spray cooling using flow symmetric micro-structured surfaces

Creator:: Tulchinsky, Alex M.
Abstract:: Spray impingement cooling has been shown to be a leading candidate for future high heat flux cooling applications. In general, spray cooling curves consist of three heat flux regimes; single-phase, two-phase and critical heat flux (CHF). CHF is considered the design limit for almost all two-phase cooling applications, as a...
Resource Type:: Masters Thesis
Full Text:: below the impingement surface. Results are presented as heat flux, q  , versus the wall-to-spray

Characterization of Oxide Growth of Aluminum Alloy 6061 for Nuclear Research and Test Reactors

Creator:: Wei, Youran
Abstract:: Oxide growth is a common phenomenon on aluminum alloy cladding surfaces in nuclear research and test reactors. Without better understanding of oxide growth, excessive oxide build up on the cladding surface reduces heat transfer capability from fuel to coolant and causes safety concerns due to the potential cladding rupture or...
Resource Type:: Masters Thesis
Full Text:: Fast, David Garfinkel, Fei Teng, Benjamin Adam and Lucas teeter in reviewing the thesis and providing

Technology to promote concept-based, active learning and enable education research

Creator:: Brooks, Bill J.
Abstract:: This dissertation centers on development of two web-based, in class learning tools, the AIChE Concept Warehouse (CW) and the Web-based Interactive Science and Engineering Learning Tool (WISE), and describes the investigation of student learning through their use. The intent of these tools is to promote deeper conceptual understanding in students...
Resource Type:: Dissertation
Full Text:: some funky figure formatting. In Chapter 3, Dr. Milo Koretsky and Dr. Adam Higgins contributed to the

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

Creator:: Gómez Ramirez, Luis A.
Abstract:: Decline in cardiac pump function is a hallmark of aging where mitochondrial decay is an important underlying cause. Although certainly multifactorial in nature, both dysfunction of the machinery involved in the chemiosmotic process of energy transduction and lower capacity to maintain fatty acid-driven respiration are identified as intrinsic factors of...
Resource Type:: Dissertation
Full Text:: research committee, Drs. Claudia S. Maier, Balz Frei, Joseph Beckman and Adam Higgins not only for

Geometric Chatter Stability Index for Milling and Modeling of Chip Pulling Effect

Creator:: Maulimov, Mukhtar
Abstract:: Prediction and mitigation of chatter vibrations in machining operations and optimizing overall machining mechanics are crucial for achieving greater productivity and manufacturing efficiency. This thesis first explores effect of directional relationships on chatter stability in milling process. Based on the directional relationships, a geometry-based chatter stability index (CSI) is proposed...
Resource Type:: Masters Thesis
Full Text:: would like to thank Josiah Adam Breen for his assistance with the experimental setup that is used in

Extracorporeal Treatment of Hyperuricemia via Enzymatic Functionalized Microchannel Processing Platform (iCore): Experiment and Modeling

Creator:: Pantakitcharoenkul, Jaturavit
Abstract:: Hyperuricemia is the condition of excessive presence of plasma uric acid ≥ 6 mg/dl. Conventional clinical/hospital urate-lowering treatment includes the administration of non-steroid anti-inflammatory drugs or xanthine oxidase inhibitors. Numerous drawbacks can be observed from these conventional treatments. In patients with refractory gout symptoms and tumor lysis syndrome, recombinant uricase...
Resource Type:: Dissertation
Full Text:: much from both of you. I would like to show my appreciation to Dr. Adam Higgins for allowing me to

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Creator:: Laschober, Nicole B.
Abstract:: Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
Resource Type:: Honors College Thesis
Full Text:: University _____________________________________________________________________ Adam Higgins

Microbial Electrolysis Cells for the Production of Hydrogen Gas : Evaluation of Internal Resistance and Design for Scale-Up

Creator:: Miller, Andrew G.
Abstract:: Modification of microbial electrolysis cells (MECs) by altering the sizes of the anode and the cathode, or their interaction with the liquid stream affects the performance of the MEC, but it remains difficult to quantify how much each change will contribute to the overall performance. Through this study, a method...
Resource Type:: Masters Thesis

Optimal control of an underactuated bipedal robot

Creator:: Jones, Mikhail S.
Abstract:: Bipedal robots represent a unique class of control problems that combine many of the most difficult elements of nonlinear control. These robots are typically designed to be mobile and as such have limited energy and actuator authority making efficiency a prime concern. Unlike wheeled robots, legged robots must transition between...
Resource Type:: Masters Thesis
Full Text:: . . . . . . . . . . . . 18 3.2 Inertia matrix H(q) and nonconservative force vector η(q, q̇, τ ) for the double pendulum on

ScholarsArchive@OSU

Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function

Experimental study of subcooled water spray cooling using flow symmetric micro-structured surfaces

Characterization of Oxide Growth of Aluminum Alloy 6061 for Nuclear Research and Test Reactors

Technology to promote concept-based, active learning and enable education research

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

Geometric Chatter Stability Index for Milling and Modeling of Chip Pulling Effect

Extracorporeal Treatment of Hyperuricemia via Enzymatic Functionalized Microchannel Processing Platform (iCore): Experiment and Modeling

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Microbial Electrolysis Cells for the Production of Hydrogen Gas : Evaluation of Internal Resistance and Design for Scale-Up

Optimal control of an underactuated bipedal robot

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