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Filtering by: Subject Phenylbutazone -- Physiological effect Committee Member Ho, Emily Committee Member Tanguay, Robert Language English [eng]

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:

Madeen, Erin

Abstract:

The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...

Resource Type:

Dissertation

Full Text:

comparison [32]. 8 The effect of the “responsive” Ahrb-1 allele (expressed as a hemizygote
Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

Creator:

Coleman, Daniel J.

Abstract:

Melanoma is the deadliest form of skin cancer, arising from malignant transformation of pigment-producing melanocytes. The primary risk factor for melanoma and other skin cancers is DNA damage resulting from unprotected solar ultraviolet radiation (UVR). If incorrectly repaired, this damage can result in incorporation of mutations that cause aberrant cell...

Resource Type:

Dissertation

Full Text:

-γ available in the microenvironment which has a negative effect on post-UVR survival of