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Filtering by: Creator Heck, Samuel T. Remove constraint Creator: Heck, Samuel T. Committee Member Ho, Emily Remove constraint Committee Member: Ho, Emily Contributor Bradford, C. Samuel Remove constraint Contributor: Bradford, C. Samuel

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  • From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

    Creator:
    Meeuwsen, Joseph C.
    Abstract:
    Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
    Resource Type:
    Dissertation
    Full Text:
    . Samuel Bradford, Dr. Pamela Beilby, Dr. James Hurst, and Dr. John Sirois – thank you for your advice