Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Committee Member Ho, Emily Degree Field Biochemistry and Biophysics

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:

Smith, Eric Jonathan

Abstract:

Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...

Resource Type:

Dissertation
Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:

Nian, Hui

Abstract:

Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...

Resource Type:

Dissertation
Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

Creator:

Vanegas, Juan Manuel

Abstract:

The unfolding of human retinoid X receptor α in the presence of the denaturant guanidine HCl was studied using stopped-flow absorbance spectroscopy. The protein's four native cysteine residues were mutated to obtain four single-cysteine mutants, each with the other three cysteine residues mutated to alanine. The thiols of these hRXRα...

Resource Type:

Masters Thesis