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Filtering by: Subject Phenylbutazone -- Physiological effect Remove constraint Subject: Phenylbutazone -- Physiological effect Committee Member Ho, Emily Remove constraint Committee Member: Ho, Emily Degree Field Molecular and Cellular Biology Remove constraint Degree Field: Molecular and Cellular Biology

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  • Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

    Creator:
    Coleman, Daniel J.
    Abstract:
    Melanoma is the deadliest form of skin cancer, arising from malignant transformation of pigment-producing melanocytes. The primary risk factor for melanoma and other skin cancers is DNA damage resulting from unprotected solar ultraviolet radiation (UVR). If incorrectly repaired, this damage can result in incorporation of mutations that cause aberrant cell...
    Resource Type:
    Dissertation
    Full Text:
    -γ available in the microenvironment which has a negative effect on post-UVR survival of