Index Catalog // ScholarsArchive@OSU

Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

Creator:: Fei, Xiaobo
Abstract:: Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
Resource Type:: Masters Thesis
Full Text:: Gene Predicted function Gene Predicted function RC SQPOA B D E F G H I J K L M Nvio Tvph vioA NRPS(A

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:: Smith, Eric Jonathan
Abstract:: Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Resource Type:: Dissertation
Full Text:: , Emily Ho, Gary Merrill, and Jean Hall. In the process of building this body of work I have

Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

Creator:: Vanegas, Juan Manuel
Abstract:: The unfolding of human retinoid X receptor α in the presence of the denaturant guanidine HCl was studied using stopped-flow absorbance spectroscopy. The protein's four native cysteine residues were mutated to obtain four single-cysteine mutants, each with the other three cysteine residues mutated to alanine. The thiols of these hRXRα...
Resource Type:: Masters Thesis
Full Text:: , k'obs = 7.17 ± 0.12 s -1, k''obs = 0.173 ± 0.001 s -1. (B) Slow region fitted to eq. 1: B = 0.11900

Changes in body composition and metabolic syndrome risk factors : response to energy-restriction, protein intake, and high intensity interval training

Creator:: Pilolla, Kari D.
Abstract:: Metabolic syndrome (MetS) and abdominal obesity (AbOb) increase the risk of developing cardiovascular disease and diabetes. Energy restriction (ER), highprotein (PRO) intake and high-intensity interval training (HIT) can independently improve MetS and AbOb. However, ER reduces metabolically active lean body mass (LBM) in addition to body fat (BF). Purpose: To...
Resource Type:: Dissertation
Full Text:: thankful for the support provided by Drs. Emily Ho, Darlene Russ-Eft, Gianni Maddalozzo, Laurel Kincl

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

Creator:: Sengupta, Sumitra
Abstract:: Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
Resource Type:: Dissertation
Full Text:: . I will always look up to him as a great source of inspiration. I also want to thank Dr. Lijoy K

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Creator:: Shorey, Lyndsey E.
Abstract:: Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Resource Type:: Dissertation
Full Text:: mentors including my committee members Drs. Andrew Buermeyer, Valerian Dolja, Michael Freitag, and Emily

Comparative Metagenomic Investigations Link the Functional Capacity of the Gut Microbiome to Vertebrate Physiology

Creator:: Armour, Courtney R.
Abstract:: Microscopic organisms inhabit virtually every niche on this planet, where they perform functions vital to all life on earth. Accordingly, humans host a complex community of microorganisms (i.e. the gut microbiome) that inhabit the gastrointestinal tract and modulate host physiology. Insight into the specific mechanisms through which gut microbes influence...
Resource Type:: Dissertation

Contractile function and calpain activity in mouse skeletal muscle during hypoxia

Creator:: Hu, Hui
Abstract:: Calcium activated proteases, or calpains, are activated in cardiac muscles under conditions of ischemia/reperfusion and hypoxia. Their activity in skeletal muscle under similar conditions is poorly understood. We tested the hypothesis that hypoxia elevates calpain-mediated proteolysis in isolated glycolytic (extensor digitorum longus, EDL) and oxidative (soleus, SOL) mouse muscles studied...
Resource Type:: Masters Thesis
Full Text:: sincere appreciation goes to all of my committee members: Dr Emily Ho, for allowing me to use her lab

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: Rodriguez-Proteau, William Baird, and Emily Ho for their active support as committee members throughout my

Development of a Bioluminescent Sensor of Isothiocyanates through Genetic Modification of Pseudomonas fluorescens and Validation on Crude Plant Materials

Creator:: Hogaboam, Octavia L.
Abstract:: Isothiocyanates (ITCs) are produced by roots in a variety of agricultural plants, such as those within the Brassicaceae family. ITCs act as fumigants, and are used to control microbial plant pathogens by adding brassica-origin seed meal to soil prior to replanting. However, there is suggestion that the presence of residual...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Emily Ho, Committee, representing College of Public Health and Human Sciences

ScholarsArchive@OSU

Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

Changes in body composition and metabolic syndrome risk factors : response to energy-restriction, protein intake, and high intensity interval training

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Comparative Metagenomic Investigations Link the Functional Capacity of the Gut Microbiome to Vertebrate Physiology

Contractile function and calpain activity in mouse skeletal muscle during hypoxia

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Development of a Bioluminescent Sensor of Isothiocyanates through Genetic Modification of Pseudomonas fluorescens and Validation on Crude Plant Materials

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