Index Catalog // ScholarsArchive@OSU

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Creator:: Shorey, Lyndsey E.
Abstract:: Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Resource Type:: Dissertation
Full Text:: Acute T-cell Lymphoblastic Leukemia/lymphoma. Abstract approved: David E. Williams

Oxidative stress and muscle dysfunction following anterior cruciate ligament surgery

Creator:: Barker, Tyler
Abstract:: Despite the advances in surgery, physical therapy, and pharmaceutical agents, muscle dysfunction (i.e., atrophy and weakness) continues to impair recovery from an anterior cruciate ligament (ACL) injury and surgery. Ischemia-reperfusion injury during surgery and the subsequent limb disuse are two events experienced by patients having ACL surgery. Oxidative stress and...
Resource Type:: Dissertation
Full Text:: stress and inflammation were evaluated in the circulation and muscle. Plasma α-tocopherol (α-T) and

Contractile function and calpain activity in mouse skeletal muscle during hypoxia

Creator:: Hu, Hui
Abstract:: Calcium activated proteases, or calpains, are activated in cardiac muscles under conditions of ischemia/reperfusion and hypoxia. Their activity in skeletal muscle under similar conditions is poorly understood. We tested the hypothesis that hypoxia elevates calpain-mediated proteolysis in isolated glycolytic (extensor digitorum longus, EDL) and oxidative (soleus, SOL) mouse muscles studied...
Resource Type:: Masters Thesis
Full Text:: troponin T (TnT) and troponin I (TnI). Ischemia/hypoxia and myocardial function Myocardial ischemia

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:: Larsen, Christine A.
Abstract:: Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Resource Type:: Dissertation

Metabolic and Renal Effects of Consumption of Five Phytochemicals in High-Fat Fed C57BL6J Mice

Creator:: Hansen, Allysa
Abstract:: A significant body of research demonstrates that phytochemical intake favorably influences hepatic metabolism via a number of different biological mechanisms. Other research has shown a positive effect of certain phytochemicals on kidney health, specifically in ameliorating symptoms of kidney disease. The current research used three separate studies that tested the...
Resource Type:: Masters Thesis
Full Text:: , neutrophils, T-cells, B- cells, and mast cells in adipose tissue (Kanneganti and Dixit, 2012). Although

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: mice develop an aggressive lymphosarcoma of T-cell origin producing mortalities as early as 12 weeks

Effect of Agronomically Selenium Biofortified Hay on Oxidative Status, Metabolic and Inflammatory Biomarkers, and Immune Response of Transition Primiparous Dairy Cows and Se Transfer and Glutathione Peroxidase Activity in their Calves

Creator:: Jaaf, Shana S.
Abstract:: During the peripartum period (3 weeks before through 3 weeks after calving, a.k.a. “transition”), high producing dairy cows experience, among others, , oxidative stress and immune suppression that compromise performance and increased incidence of diseases.Among trace minerals, supplementation of Selenium (Se) can help to improve the transition by enhancing glutathione...
Resource Type:: Dissertation
Full Text:: (P≤0.05) effects of Selenium (TRT), breed (B), and time (T) and their interactions are indicated by

Western Diet-Induced Nonalcoholic Steatohepatitis (NASH): The Impact of Time on the Onset and Remission of Disease

Creator:: Spooner, Melinda H.
Abstract:: Nonalcoholic fatty liver disease (NAFLD) is characterized by an accumulation of neutral lipids in the form of triglycerides and cholesterol esters accounting for >5% of liver weight. Excess neutral lipids accumulate in large lipid droplets, i.e., macrosteatosis, displacing the nucleus of cells. Current theory suggests neutral lipid accumulation is the...
Resource Type:: Dissertation
Full Text:: (Kupffer cells), infiltrating monocytes, T cells, and polarized pro-inflammatory (M1) and anti

In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

Creator:: Cardenas, Andres
Abstract:: Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
Resource Type:: Dissertation
Full Text:: utero had an increased risk for CHD in adulthood (Painter et al., 2006; T. J. Roseboom et al., 2000

Reversing menstrual dysfunction (REMEDY) : the impact of menstrual status on musculoskeletal and hormonal health

Creator:: Kam, Lynn Cialdella
Abstract:: Menstrual dysfunction (MD), possibly due to lower energy availability (EA), is prevalent in active women and associated with unfavorable heath consequences. PURPOSE: To determine if EA improvements in endurance-trained women, using a daily Carbohydrate-Protein supplement (CHO-PRO), will restore menstrual function and improve musculoskeletal health. METHODS: Athletes with MD (ExMD; n=8;...
Resource Type:: Dissertation

ScholarsArchive@OSU

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Oxidative stress and muscle dysfunction following anterior cruciate ligament surgery

Contractile function and calpain activity in mouse skeletal muscle during hypoxia

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Metabolic and Renal Effects of Consumption of Five Phytochemicals in High-Fat Fed C57BL6J Mice

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Effect of Agronomically Selenium Biofortified Hay on Oxidative Status, Metabolic and Inflammatory Biomarkers, and Immune Response of Transition Primiparous Dairy Cows and Se Transfer and Glutathione Peroxidase Activity in their Calves

Western Diet-Induced Nonalcoholic Steatohepatitis (NASH): The Impact of Time on the Onset and Remission of Disease

In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

Reversing menstrual dysfunction (REMEDY) : the impact of menstrual status on musculoskeletal and hormonal health

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