Index Catalog // ScholarsArchive@OSU

Modulation of metabolic syndrome by soy isoflavones : in-vitro and in-vivo models

Creator:: Luo, Ting
Abstract:: Metabolic syndrome is a problem affecting people around the world. In a number of studies, soy intake has been documented to possess antidiabetic and anticardiovascular effect. My project is focused on the impact of the intake of compounds found within soy, the isoflavones, their impact on metabolic syndrome symptoms, and...
Resource Type:: Dissertation
Full Text:: daidzein (WD+D) for 10 weeks. Surprisingly, intake of WD+G and WD+D significantly decreased food intake

Sesame oil increases plasma γ-tocopherol and inhibits γ-tocopherol metabolism in humans

Creator:: Lee, Sangeun
Abstract:: In rats, sesame lignans increase plasma γ-tocopherol concentrations and inhibit γ-tocopherol degradation to its metabolite γ-carboxyethylhydroxychroman (γ-CEHC). To test if sesame lignan consumption inhibits γ- tocopherol metabolism in humans, muffins prepared with either corn oil (control) or sesame oil and an equimolar mixture of deuterium labeled d6-α- and d2-γ- tocopheryl...
Resource Type:: Masters Thesis
Full Text:: /d) for 4 weeks demonstrated a 42% increase in serum γ-tocopherol concentrations (88

Comparative Metagenomic Investigations Link the Functional Capacity of the Gut Microbiome to Vertebrate Physiology

Creator:: Armour, Courtney R.
Abstract:: Microscopic organisms inhabit virtually every niche on this planet, where they perform functions vital to all life on earth. Accordingly, humans host a complex community of microorganisms (i.e. the gut microbiome) that inhabit the gastrointestinal tract and modulate host physiology. Insight into the specific mechanisms through which gut microbes influence...
Resource Type:: Dissertation
Full Text:: Machinery's Special Interest Group on High Performance Computing, Intel, Larry W. Martin and Joyce B

Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

Creator:: Larkey, Nicholas E.
Abstract:: One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
Resource Type:: Dissertation
Full Text:: N. Brucks developed the MATLAB code used to originate sensor sequences. Shan S. Lansing, Sophia D

The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

Creator:: Conley, Melissa N.
Abstract:: Osteoporosis is a common metabolic bone disease, affecting a third of women and a fifth of men over age 65. In the US, annual health care costs associated with osteoporosis are estimated to be over $20 billion. Osteoporosis is associated with increased fracture risk, which has been demonstrated to predict...
Resource Type:: Dissertation
Full Text:: , BFR/B.Pm), or d) osteoclast perimeter (osteoclast perimeter / bone perimeter, Oc.Pm/B.Pm) in the

Polyunsaturated fatty acid synthesis and type 2 diabetes complications

Creator:: Tripathy, Sasmita
Abstract:: Type 2 diabetes mellitus (T2DM) is a disease of multi-complications affecting more than 20 million US adults. Hyperglycemia is the classic clinical feature of diabetes, and uncontrolled hyperglycemia leads to deadly health complications. Thus, control of blood glucose represents a major goal for diabetics. Human and rodent studies revealed another...
Resource Type:: Dissertation

Identifying Differences in the Release of Bioactive Milk Peptides Across the Intestinal Tract Between Term and Preterm Infants

Creator:: Beverly, Robert L.
Abstract:: Premature birth interrupts the typical development of the human fetus, leaving the infant born with underdeveloped gastrointestinal and immune systems. Preterm infants have reduced stomach acidity, reduced digestive protease activity, more permeable intestinal membranes, impaired innate and adaptive immune response, and poor microbiome development. Due to these factors, preterm infants...
Resource Type:: Dissertation
Full Text:: preterm 8/9 and preterm 21/22 (C) and preterm 8/9 and term 8/9 (D), and combined α-lactalbumin and

Effect of Agronomically Selenium Biofortified Hay on Oxidative Status, Metabolic and Inflammatory Biomarkers, and Immune Response of Transition Primiparous Dairy Cows and Se Transfer and Glutathione Peroxidase Activity in their Calves

Creator:: Jaaf, Shana S.
Abstract:: During the peripartum period (3 weeks before through 3 weeks after calving, a.k.a. “transition”), high producing dairy cows experience, among others, , oxidative stress and immune suppression that compromise performance and increased incidence of diseases.Among trace minerals, supplementation of Selenium (Se) can help to improve the transition by enhancing glutathione...
Resource Type:: Dissertation
Full Text:: concentration of Se in whole blood (A), liver (C), and milk (D) and glutathione peroxidase (GPx) activity in

Western Diet-Induced Nonalcoholic Steatohepatitis (NASH): The Impact of Time on the Onset and Remission of Disease

Creator:: Spooner, Melinda H.
Abstract:: Nonalcoholic fatty liver disease (NAFLD) is characterized by an accumulation of neutral lipids in the form of triglycerides and cholesterol esters accounting for >5% of liver weight. Excess neutral lipids accumulate in large lipid droplets, i.e., macrosteatosis, displacing the nucleus of cells. Current theory suggests neutral lipid accumulation is the...
Resource Type:: Dissertation

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

Creator:: Depner, Christopher Michael
Abstract:: Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...
Resource Type:: Dissertation

ScholarsArchive@OSU

Modulation of metabolic syndrome by soy isoflavones : in-vitro and in-vivo models

Sesame oil increases plasma γ-tocopherol and inhibits γ-tocopherol metabolism in humans

Comparative Metagenomic Investigations Link the Functional Capacity of the Gut Microbiome to Vertebrate Physiology

Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

Polyunsaturated fatty acid synthesis and type 2 diabetes complications

Identifying Differences in the Release of Bioactive Milk Peptides Across the Intestinal Tract Between Term and Preterm Infants

Effect of Agronomically Selenium Biofortified Hay on Oxidative Status, Metabolic and Inflammatory Biomarkers, and Immune Response of Transition Primiparous Dairy Cows and Se Transfer and Glutathione Peroxidase Activity in their Calves

Western Diet-Induced Nonalcoholic Steatohepatitis (NASH): The Impact of Time on the Onset and Remission of Disease

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

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