Index Catalog // ScholarsArchive@OSU

Sesame oil increases plasma γ-tocopherol and inhibits γ-tocopherol metabolism in humans

Creator:: Lee, Sangeun
Abstract:: In rats, sesame lignans increase plasma γ-tocopherol concentrations and inhibit γ-tocopherol degradation to its metabolite γ-carboxyethylhydroxychroman (γ-CEHC). To test if sesame lignan consumption inhibits γ- tocopherol metabolism in humans, muffins prepared with either corn oil (control) or sesame oil and an equimolar mixture of deuterium labeled d6-α- and d2-γ- tocopheryl...
Resource Type:: Masters Thesis
Full Text:: -tocopherol metabolism in humans AN ABSTRACT OF THE THESIS OF Sangeun Lee for the degree of Master

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:: Nian, Hui
Abstract:: Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
Resource Type:: Dissertation

Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

Creator:: Larkey, Nicholas E.
Abstract:: One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
Resource Type:: Dissertation

Metabolic and Renal Effects of Consumption of Five Phytochemicals in High-Fat Fed C57BL6J Mice

Creator:: Hansen, Allysa
Abstract:: A significant body of research demonstrates that phytochemical intake favorably influences hepatic metabolism via a number of different biological mechanisms. Other research has shown a positive effect of certain phytochemicals on kidney health, specifically in ameliorating symptoms of kidney disease. The current research used three separate studies that tested the...
Resource Type:: Masters Thesis

The role of copper and its chelation by tetrathiomolybdate in inflammation and atherosclerosis

Creator:: Wei, Hao
Abstract:: Endothelial activation with increased expression of cellular adhesion molecules, chemokines and pro-inflammatory cytokines critically contributes to vascular inflammation and the initiation and progression of atherosclerosis. By affecting redox-sensitive cell signaling pathways and transcription factors, redox-active transition metal ions, such as copper and iron, may play an important role in these...
Resource Type:: Dissertation

Efficacy of the Wellness Focused “Be Orange Challenge” with Tracking to Promote Healthy Behavior Change

Creator:: Miller, Aimee S.
Abstract:: Purpose: Many programs are available to engage people in health-promoting behaviors or behavior change, but most target specific behavior outcomes (e.g., weight loss, smoking cessation) rather than wellness. This study aimed to assess the effectiveness of a tracking-based health challenge focused on overall wellness, with or without peer support. Methods:...
Resource Type:: Honors College Thesis
Full Text:: . 24 References 1. Blair SN, Horton E, Leon AS, Lee IM, Drinkwater BL, Dishman RK, et al. Physical

Oxidative stress and muscle dysfunction following anterior cruciate ligament surgery

Creator:: Barker, Tyler
Abstract:: Despite the advances in surgery, physical therapy, and pharmaceutical agents, muscle dysfunction (i.e., atrophy and weakness) continues to impair recovery from an anterior cruciate ligament (ACL) injury and surgery. Ischemia-reperfusion injury during surgery and the subsequent limb disuse are two events experienced by patients having ACL surgery. Oxidative stress and...
Resource Type:: Dissertation

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:: Smith, Eric Jonathan
Abstract:: Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Resource Type:: Dissertation

Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

Creator:: Coleman, Daniel J.
Abstract:: Melanoma is the deadliest form of skin cancer, arising from malignant transformation of pigment-producing melanocytes. The primary risk factor for melanoma and other skin cancers is DNA damage resulting from unprotected solar ultraviolet radiation (UVR). If incorrectly repaired, this damage can result in incorporation of mutations that cause aberrant cell...
Resource Type:: Dissertation

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation

ScholarsArchive@OSU

Sesame oil increases plasma γ-tocopherol and inhibits γ-tocopherol metabolism in humans

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

Metabolic and Renal Effects of Consumption of Five Phytochemicals in High-Fat Fed C57BL6J Mice

The role of copper and its chelation by tetrathiomolybdate in inflammation and atherosclerosis

Efficacy of the Wellness Focused “Be Orange Challenge” with Tracking to Promote Healthy Behavior Change

Oxidative stress and muscle dysfunction following anterior cruciate ligament surgery

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

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