Index Catalog // ScholarsArchive@OSU

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:: Larsen, Christine A.
Abstract:: Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Resource Type:: Dissertation
Full Text:: Doctor of Philosophy dissertation of Christine A AN

Understanding health behavior influences of undergraduate students during college transition

Creator:: Hart, Kerry A.
Abstract:: As college students transition to life away from their parental home, the need to make independent decisions regarding their eating and exercise behaviors is evident. This life transition may be a critical period for establishment of long term behavior patterns with potential impact on health, disease and weight balance. This...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Kerry A. Hart for the

The genus Caenorhabditis : a system for testing evolutionary questions

Creator:: Raboin, Michael J.
Abstract:: Caenorhabditis elegans is arguably the best understood animal on the planet. Used for over 50 years to study development, we have a vast amount of knowledge of the inner workings of this worm. Our knowledge is incomplete, however, without placing this organism in its evolutionary and ecological context. In this...
Resource Type:: Dissertation
Full Text:: . Title: The Genus Caenorhabditis : A System for Testing Evolutionary Questions Abstract approved

From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

Creator:: Meeuwsen, Joseph C.
Abstract:: Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
Resource Type:: Dissertation
Full Text:: intermediates in ALS. A major goal for recent therapeutic interventions for ALS, therefore, is to avoid the

The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

Creator:: Conley, Melissa N.
Abstract:: Osteoporosis is a common metabolic bone disease, affecting a third of women and a fifth of men over age 65. In the US, annual health care costs associated with osteoporosis are estimated to be over $20 billion. Osteoporosis is associated with increased fracture risk, which has been demonstrated to predict...
Resource Type:: Dissertation
Full Text:: . Dietary nitrate had no effect on a) mineral apposition rate (MAR), b) mineralizing perimeter

Metabolic effects of consumption of quercetin, ellagic acid, cherry, and apple phytochemical extracts in high-fat fed mice

Creator:: Smith, Sarah M.
Abstract:: Metabolic improvements and changes in gene expression were measured in mice fed polyphenol-rich extracts derived from apples and sweet cherries, and the common phytochemicals, quercetin and ellagic acid. Polyphenol-rich extracts were produced by solid phase extraction and column chromatography. Extracts and purified compounds were mixed into a high-fat (HF, 60%...
Resource Type:: Masters Thesis
Full Text:: chromatography. Extracts and purified compounds were mixed into a high-fat (HF, 60% of total kcal) obesigenic

Metabolic and Renal Effects of Consumption of Five Phytochemicals in High-Fat Fed C57BL6J Mice

Creator:: Hansen, Allysa
Abstract:: A significant body of research demonstrates that phytochemical intake favorably influences hepatic metabolism via a number of different biological mechanisms. Other research has shown a positive effect of certain phytochemicals on kidney health, specifically in ameliorating symptoms of kidney disease. The current research used three separate studies that tested the...
Resource Type:: Masters Thesis
Full Text:: Neil F. Shay A significant body of research demonstrates that phytochemical intake favorably

In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

Creator:: Cardenas, Andres
Abstract:: Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
Resource Type:: Dissertation
Full Text:: gestational age was mediated through CpG methylation of infant cord-blood, which is a critical parameter of

Changes in body composition and metabolic syndrome risk factors : response to energy-restriction, protein intake, and high intensity interval training

Creator:: Pilolla, Kari D.
Abstract:: Metabolic syndrome (MetS) and abdominal obesity (AbOb) increase the risk of developing cardiovascular disease and diabetes. Energy restriction (ER), highprotein (PRO) intake and high-intensity interval training (HIT) can independently improve MetS and AbOb. However, ER reduces metabolically active lean body mass (LBM) in addition to body fat (BF). Purpose: To...
Resource Type:: Dissertation
Full Text:: fat (BF). Purpose: To determine the effects of a 16-wk ER diet with 2 levels of PRO (15% or 25% of

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

Creator:: Sengupta, Sumitra
Abstract:: Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
Resource Type:: Dissertation
Full Text:: the early life stage model as a powerful platform to study regeneration. Utilizing this model we

ScholarsArchive@OSU

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Understanding health behavior influences of undergraduate students during college transition

The genus Caenorhabditis : a system for testing evolutionary questions

From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

Metabolic effects of consumption of quercetin, ellagic acid, cherry, and apple phytochemical extracts in high-fat fed mice

Metabolic and Renal Effects of Consumption of Five Phytochemicals in High-Fat Fed C57BL6J Mice

In Utero Exposure to Arsenic and Mercury : Epigenome-Wide Associations and Newborn Health Outcomes

Changes in body composition and metabolic syndrome risk factors : response to energy-restriction, protein intake, and high intensity interval training

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

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