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Filtering by: Subject Molybdates -- Therapeutic use Remove constraint Subject: Molybdates -- Therapeutic use Committee Member Ho, Emily Remove constraint Committee Member: Ho, Emily

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  • The role of copper and its chelation by tetrathiomolybdate in inflammation and atherosclerosis

    Creator:
    Wei, Hao
    Abstract:
    Endothelial activation with increased expression of cellular adhesion molecules, chemokines and pro-inflammatory cytokines critically contributes to vascular inflammation and the initiation and progression of atherosclerosis. By affecting redox-sensitive cell signaling pathways and transcription factors, redox-active transition metal ions, such as copper and iron, may play an important role in these...
    Resource Type:
    Dissertation
    Full Text:
    proposed as one potential therapeutic target for treatment of atherosclerosis [86, 89]. Studies evolving

  • Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

    Creator:
    Depner, Christopher Michael
    Abstract:
    Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...
    Resource Type:
    Dissertation
    Full Text:
    was to establish the therapeutic efficacy of (n-3) PUFA supplementation as a treatment modality for