Index Catalog // ScholarsArchive@OSU

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation
Full Text:: im en ta l d es ig n o f D B P e xp o su re in o ff sp ri n g. P re gn an t m

Oxidative stress and muscle dysfunction following anterior cruciate ligament surgery

Creator:: Barker, Tyler
Abstract:: Despite the advances in surgery, physical therapy, and pharmaceutical agents, muscle dysfunction (i.e., atrophy and weakness) continues to impair recovery from an anterior cruciate ligament (ACL) injury and surgery. Ischemia-reperfusion injury during surgery and the subsequent limb disuse are two events experienced by patients having ACL surgery. Oxidative stress and...
Resource Type:: Dissertation
Full Text:: Following Anterior Cruciate Ligament Surgery. Abstract approved: Maret G. Traber

The role of copper and its chelation by tetrathiomolybdate in inflammation and atherosclerosis

Creator:: Wei, Hao
Abstract:: Endothelial activation with increased expression of cellular adhesion molecules, chemokines and pro-inflammatory cytokines critically contributes to vascular inflammation and the initiation and progression of atherosclerosis. By affecting redox-sensitive cell signaling pathways and transcription factors, redox-active transition metal ions, such as copper and iron, may play an important role in these...
Resource Type:: Dissertation

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:: Nian, Hui
Abstract:: Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
Resource Type:: Dissertation
Full Text:: sulfoxides (5‐14 mg/g), and γ‐glutamyl‐S‐ trans‐1‐propenylcysteine (3‐9mg/g) is the most abundant of the γ

Reversing menstrual dysfunction (REMEDY) : the impact of menstrual status on musculoskeletal and hormonal health

Creator:: Kam, Lynn Cialdella
Abstract:: Menstrual dysfunction (MD), possibly due to lower energy availability (EA), is prevalent in active women and associated with unfavorable heath consequences. PURPOSE: To determine if EA improvements in endurance-trained women, using a daily Carbohydrate-Protein supplement (CHO-PRO), will restore menstrual function and improve musculoskeletal health. METHODS: Athletes with MD (ExMD; n=8;...
Resource Type:: Dissertation
Full Text:: friends. First, I would like to thank my husband, Mitch, and R&G for their love, patience, and support

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Creator:: Shorey, Lyndsey E.
Abstract:: Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Resource Type:: Dissertation
Full Text:: are a rich source of glucosinolates at approximately 20 μmol/g of plant material [72

The genus Caenorhabditis : a system for testing evolutionary questions

Creator:: Raboin, Michael J.
Abstract:: Caenorhabditis elegans is arguably the best understood animal on the planet. Used for over 50 years to study development, we have a vast amount of knowledge of the inner workings of this worm. Our knowledge is incomplete, however, without placing this organism in its evolutionary and ecological context. In this...
Resource Type:: Dissertation
Full Text:: underlying genetic factors (Seidel et al., 2008; Ross et al., 2011); for C. elegans, higher resolution

Vitamin E and K interactions : investigating mechanisms of reduced vitamin K status in response to excess vitamin E

Creator:: Farley, Sherry Mae
Abstract:: The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
Resource Type:: Dissertation
Full Text:: Status in Response to Excess Vitamin E Abstract approved: Maret G. Traber The primary goal

Changes in body composition and metabolic syndrome risk factors : response to energy-restriction, protein intake, and high intensity interval training

Creator:: Pilolla, Kari D.
Abstract:: Metabolic syndrome (MetS) and abdominal obesity (AbOb) increase the risk of developing cardiovascular disease and diabetes. Energy restriction (ER), highprotein (PRO) intake and high-intensity interval training (HIT) can independently improve MetS and AbOb. However, ER reduces metabolically active lean body mass (LBM) in addition to body fat (BF). Purpose: To...
Resource Type:: Dissertation

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

Creator:: Depner, Christopher Michael
Abstract:: Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...
Resource Type:: Dissertation
Full Text:: are most susceptible to NAFLD and most highly express the PNPLA3 (rs738409[G]) allele associated

ScholarsArchive@OSU

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Oxidative stress and muscle dysfunction following anterior cruciate ligament surgery

The role of copper and its chelation by tetrathiomolybdate in inflammation and atherosclerosis

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Reversing menstrual dysfunction (REMEDY) : the impact of menstrual status on musculoskeletal and hormonal health

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

The genus Caenorhabditis : a system for testing evolutionary questions

Vitamin E and K interactions : investigating mechanisms of reduced vitamin K status in response to excess vitamin E

Changes in body composition and metabolic syndrome risk factors : response to energy-restriction, protein intake, and high intensity interval training

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

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