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Western Diet-Induced Nonalcoholic Steatohepatitis (NASH): The Impact of Time on the Onset and Remission of Disease

Creator:: Spooner, Melinda H.
Abstract:: Nonalcoholic fatty liver disease (NAFLD) is characterized by an accumulation of neutral lipids in the form of triglycerides and cholesterol esters accounting for >5% of liver weight. Excess neutral lipids accumulate in large lipid droplets, i.e., macrosteatosis, displacing the nucleus of cells. Current theory suggests neutral lipid accumulation is the...
Resource Type:: Dissertation
Full Text:: resulting in nonalcoholic steatohepatitis (NASH) (1-3, 7, 8, 13, 14). Excessive hepatic injury arising

Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

Creator:: Coleman, Daniel J.
Abstract:: Melanoma is the deadliest form of skin cancer, arising from malignant transformation of pigment-producing melanocytes. The primary risk factor for melanoma and other skin cancers is DNA damage resulting from unprotected solar ultraviolet radiation (UVR). If incorrectly repaired, this damage can result in incorporation of mutations that cause aberrant cell...
Resource Type:: Dissertation
Full Text:: 14 regression of melanomas in mice expressing NRASQ61K [51], but interestingly only when CDK4/6

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:: Nian, Hui
Abstract:: Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
Resource Type:: Dissertation
Full Text:: .............................................. 13 1.3.3 Mechanisms of cancer prevention by natural seleno‐compounds ...................... 14

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Creator:: Shorey, Lyndsey E.
Abstract:: Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Resource Type:: Dissertation
Full Text:: offspring both gestating in and nursed by an exposed female. [ 14 C]-DBC (GD17) dosing was utilized to

Use and Disclosure of Complementary Health Approaches Among Children with Developmental Disabilities

Creator:: Lindly, Olivia J.
Abstract:: Children with developmental disabilities (DD), particularly autism spectrum disorder (ASD), may use complementary health approaches (CHA), including some modalities that can be unsafe, inefficacious, and/or costly. Still, the prevalence of CHA use among US children with DD is not known and their reasons for use are not well understood. By...
Resource Type:: Dissertation
Full Text:: ..................................................................................................................................... 14 Introduction

The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

Creator:: Conley, Melissa N.
Abstract:: Osteoporosis is a common metabolic bone disease, affecting a third of women and a fifth of men over age 65. In the US, annual health care costs associated with osteoporosis are estimated to be over $20 billion. Osteoporosis is associated with increased fracture risk, which has been demonstrated to predict...
Resource Type:: Dissertation
Full Text:: women [9]. However, it remains to be shown if these data are associated with the development of 14

Changes in body composition and metabolic syndrome risk factors : response to energy-restriction, protein intake, and high intensity interval training

Creator:: Pilolla, Kari D.
Abstract:: Metabolic syndrome (MetS) and abdominal obesity (AbOb) increase the risk of developing cardiovascular disease and diabetes. Energy restriction (ER), highprotein (PRO) intake and high-intensity interval training (HIT) can independently improve MetS and AbOb. However, ER reduces metabolically active lean body mass (LBM) in addition to body fat (BF). Purpose: To...
Resource Type:: Dissertation
Full Text:: Satiety is especially high after consuming a higher protein morning meal (0.867g/kg BW).14 In addition

The Influence of Vineyard and Winery Nitrogen Supplementation on Chardonnay and Pinot Noir Winemaking and Wine Quality

Creator:: Ruppel, Meghan L.
Abstract:: Nitrogen is a crucial nutrient required by yeast to successfully complete alcoholic fermentation. In particular, the concentration of yeast assimilable nitrogen (YAN) influences fermentation kinetics and the production of a range of volatile aroma compounds, both desirable and undesirable. YAN is naturally present in the grape, but producers can boost...
Resource Type:: Masters Thesis
Full Text:: …….………................…………………...14 Chapter 2 Changes In Grape Juice Chemistry And Fermentation Kinetics Due To Nitrogen

DHA and Low-fat Low-cholesterol Diets as Treatment Strategies for Nonalcoholic Fatty Liver Disease

Creator:: Lytle, Kelli Anne
Abstract:: Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess neutral lipids within the parenchymal cells of the liver. The primary etiology is diet-induced and most often exists as a comorbidity with obesity, metabolic syndrome, and/or Type 2 Diabetes. The development of excess liver lipid can be self-limiting...
Resource Type:: Dissertation
Full Text:: and more than 14 drinks on average per week for women be considered “significant” alcohol

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

Creator:: Depner, Christopher Michael
Abstract:: Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...
Resource Type:: Dissertation
Full Text:: NAFLD activity score (NAS) was developed [18]. The NAS is a composite of 14 histological features that

ScholarsArchive@OSU

Western Diet-Induced Nonalcoholic Steatohepatitis (NASH): The Impact of Time on the Onset and Remission of Disease

Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma

Use and Disclosure of Complementary Health Approaches Among Children with Developmental Disabilities

The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

Changes in body composition and metabolic syndrome risk factors : response to energy-restriction, protein intake, and high intensity interval training

The Influence of Vineyard and Winery Nitrogen Supplementation on Chardonnay and Pinot Noir Winemaking and Wine Quality

DHA and Low-fat Low-cholesterol Diets as Treatment Strategies for Nonalcoholic Fatty Liver Disease

Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

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