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Filtering by: Creator Thompson, Gene Thomas Remove constraint Creator: Thompson, Gene Thomas Committee Member Ho, Emily Remove constraint Committee Member: Ho, Emily

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  • Comparative Metagenomic Investigations Link the Functional Capacity of the Gut Microbiome to Vertebrate Physiology

    Creator:
    Armour, Courtney R.
    Abstract:
    Microscopic organisms inhabit virtually every niche on this planet, where they perform functions vital to all life on earth. Accordingly, humans host a complex community of microorganisms (i.e. the gut microbiome) that inhabit the gastrointestinal tract and modulate host physiology. Insight into the specific mechanisms through which gut microbes influence...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Thomas J. Sharpton Microscopic organisms inhabit virtually every niche on this planet, where

  • The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

    Creator:
    Conley, Melissa N.
    Abstract:
    Osteoporosis is a common metabolic bone disease, affecting a third of women and a fifth of men over age 65. In the US, annual health care costs associated with osteoporosis are estimated to be over $20 billion. Osteoporosis is associated with increased fracture risk, which has been demonstrated to predict...
    Resource Type:
    Dissertation
    Full Text:
    component of this study, we used 16S rRNA gene sequencing to profile the composition of fecal microbiota

  • Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

    Creator:
    Fei, Xiaobo
    Abstract:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
    Resource Type:
    Masters Thesis
    Full Text:
    gene cluster cloned from Streptomyces vinaceus (ATCC11861), is shown to specifically activate

  • Metabolic and Renal Effects of Consumption of Five Phytochemicals in High-Fat Fed C57BL6J Mice

    Creator:
    Hansen, Allysa
    Abstract:
    A significant body of research demonstrates that phytochemical intake favorably influences hepatic metabolism via a number of different biological mechanisms. Other research has shown a positive effect of certain phytochemicals on kidney health, specifically in ameliorating symptoms of kidney disease. The current research used three separate studies that tested the...
    Resource Type:
    Masters Thesis
    Full Text:
    tissue saved for RNA isolation and gene expression analysis. The results of the three studies varied

  • Dietary organosulfur and organoselenium compounds as HDAC inhibitors

    Creator:
    Nian, Hui
    Abstract:
    Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
    Resource Type:
    Dissertation
    Full Text:
      activity,  and  hyperacetylated  histone  H3  was  associated with  the gene promoter. The  induction of

  • Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

    Creator:
    Castro, David J.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
    Resource Type:
    Dissertation
    Full Text:
    gene. In support of our hypothesis concerning the role of fetal cyp1b1 in DBP transplacental

  • Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

    Creator:
    Smith, Eric Jonathan
    Abstract:
    Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
    Resource Type:
    Dissertation
    Full Text:
    ’ upstream sequence of the rat Gclc gene, we identified 3 putative AREs (ARE1, ARE3, and ARE4), and one cis

  • Modulation of metabolic syndrome by soy isoflavones : in-vitro and in-vivo models

    Creator:
    Luo, Ting
    Abstract:
    Metabolic syndrome is a problem affecting people around the world. In a number of studies, soy intake has been documented to possess antidiabetic and anticardiovascular effect. My project is focused on the impact of the intake of compounds found within soy, the isoflavones, their impact on metabolic syndrome symptoms, and...
    Resource Type:
    Dissertation
    Full Text:
    diet-induced metabolic syndrome, a custom-designed gene array was utilized to determine hepatic gene

  • Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

    Creator:
    Madeen, Erin
    Abstract:
    The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
    Resource Type:
    Dissertation
    Full Text:
    of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene

  • Polyunsaturated fatty acid synthesis and type 2 diabetes complications

    Creator:
    Tripathy, Sasmita
    Abstract:
    Type 2 diabetes mellitus (T2DM) is a disease of multi-complications affecting more than 20 million US adults. Hyperglycemia is the classic clinical feature of diabetes, and uncontrolled hyperglycemia leads to deadly health complications. Thus, control of blood glucose represents a major goal for diabetics. Human and rodent studies revealed another...
    Resource Type:
    Dissertation
    Full Text:
    : Effect of Elovl5 on PPARα-regulated gene expression in mice fed a high fat diet