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Filtering by: Creator Torres, Martine I. Remove constraint Creator: Torres, Martine I. Committee Member Ho, Emily Remove constraint Committee Member: Ho, Emily

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  • Western Diet-Induced Nonalcoholic Steatohepatitis (NASH): The Impact of Time on the Onset and Remission of Disease

    Creator:
    Spooner, Melinda H.
    Abstract:
    Nonalcoholic fatty liver disease (NAFLD) is characterized by an accumulation of neutral lipids in the form of triglycerides and cholesterol esters accounting for >5% of liver weight. Excess neutral lipids accumulate in large lipid droplets, i.e., macrosteatosis, displacing the nucleus of cells. Current theory suggests neutral lipid accumulation is the...
    Resource Type:
    Dissertation
    Full Text:
    scope of recent evidence using ω3 PUFA in humans, I first conducted a review of clinical trials and

  • From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

    Creator:
    Meeuwsen, Joseph C.
    Abstract:
    Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
    Resource Type:
    Dissertation
    Full Text:
    _____________________________________________________________________ Dean of the Graduate School I understand that my dissertation will become part of the

  • Modulation of metabolic syndrome by soy isoflavones : in-vitro and in-vivo models

    Creator:
    Luo, Ting
    Abstract:
    Metabolic syndrome is a problem affecting people around the world. In a number of studies, soy intake has been documented to possess antidiabetic and anticardiovascular effect. My project is focused on the impact of the intake of compounds found within soy, the isoflavones, their impact on metabolic syndrome symptoms, and...
    Resource Type:
    Dissertation
    Full Text:
    of the Graduate School I understand that my dissertation will become part of the

  • Use and Disclosure of Complementary Health Approaches Among Children with Developmental Disabilities

    Creator:
    Lindly, Olivia J.
    Abstract:
    Children with developmental disabilities (DD), particularly autism spectrum disorder (ASD), may use complementary health approaches (CHA), including some modalities that can be unsafe, inefficacious, and/or costly. Still, the prevalence of CHA use among US children with DD is not known and their reasons for use are not well understood. By...
    Resource Type:
    Dissertation
    Full Text:
    Dean of the Graduate School I understand that my dissertation will

  • Metabolic Effects in C57B/6J Mice Fed a High-Fat Diet Supplemented With Walnuts, Raspberries and Other Whole Foods

    Creator:
    Miranda-Garcia, Omar
    Abstract:
    Health benefits obtained from consumption of fruits and vegetables have the potential to improve the lifestyle of individuals. The walnut is a polyunsaturated fatty acid (PUFA)-rich whole food that is readily available in the U.S and has been shown to potentially reduce risk of Metabolic Syndrome. Furthermore, consumption of polyphenol...
    Resource Type:
    Masters Thesis
    Full Text:
    Technology Dean of the Graduate School I understand that my thesis will become part

  • DHA and Low-fat Low-cholesterol Diets as Treatment Strategies for Nonalcoholic Fatty Liver Disease

    Creator:
    Lytle, Kelli Anne
    Abstract:
    Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess neutral lipids within the parenchymal cells of the liver. The primary etiology is diet-induced and most often exists as a comorbidity with obesity, metabolic syndrome, and/or Type 2 Diabetes. The development of excess liver lipid can be self-limiting...
    Resource Type:
    Dissertation
    Full Text:
    in LX2 cells. Moving from prevention studies, I then assessed several treatment options. First

  • Metabolic and Renal Effects of Consumption of Five Phytochemicals in High-Fat Fed C57BL6J Mice

    Creator:
    Hansen, Allysa
    Abstract:
    A significant body of research demonstrates that phytochemical intake favorably influences hepatic metabolism via a number of different biological mechanisms. Other research has shown a positive effect of certain phytochemicals on kidney health, specifically in ameliorating symptoms of kidney disease. The current research used three separate studies that tested the...
    Resource Type:
    Masters Thesis
    Full Text:
    Department of Food Science and Technology Dean of the Graduate School I

  • Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

    Creator:
    Depner, Christopher Michael
    Abstract:
    Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...
    Resource Type:
    Dissertation
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    acknowledge past and present members of the Jump lab. Dr. Moises Torres-Gonzalez who I collaborated with on

  • Polyunsaturated fatty acid synthesis and type 2 diabetes complications

    Creator:
    Tripathy, Sasmita
    Abstract:
    Type 2 diabetes mellitus (T2DM) is a disease of multi-complications affecting more than 20 million US adults. Hyperglycemia is the classic clinical feature of diabetes, and uncontrolled hyperglycemia leads to deadly health complications. Thus, control of blood glucose represents a major goal for diabetics. Human and rodent studies revealed another...
    Resource Type:
    Dissertation
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    . Moises Torres-Gonzalez; it was a great experience working with him in Elovl5 project. I would like to

  • The role of copper and its chelation by tetrathiomolybdate in inflammation and atherosclerosis

    Creator:
    Wei, Hao
    Abstract:
    Endothelial activation with increased expression of cellular adhesion molecules, chemokines and pro-inflammatory cytokines critically contributes to vascular inflammation and the initiation and progression of atherosclerosis. By affecting redox-sensitive cell signaling pathways and transcription factors, redox-active transition metal ions, such as copper and iron, may play an important role in these...
    Resource Type:
    Dissertation
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    was associated with decreased phosphorylation and degradation of its cytosolic inhibitory subunit, I