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Filtering by: Creator Yeh, Bao-Sung Remove constraint Creator: Yeh, Bao-Sung Committee Member Ho, Emily Remove constraint Committee Member: Ho, Emily

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Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

Creator:

Larkey, Nicholas E.

Abstract:

One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...

Resource Type:

Dissertation
Oxidative stress and muscle dysfunction following anterior cruciate ligament surgery

Creator:

Barker, Tyler

Abstract:

Despite the advances in surgery, physical therapy, and pharmaceutical agents, muscle dysfunction (i.e., atrophy and weakness) continues to impair recovery from an anterior cruciate ligament (ACL) injury and surgery. Ischemia-reperfusion injury during surgery and the subsequent limb disuse are two events experienced by patients having ACL surgery. Oxidative stress and...

Resource Type:

Dissertation
The role of copper and its chelation by tetrathiomolybdate in inflammation and atherosclerosis

Creator:

Wei, Hao

Abstract:

Endothelial activation with increased expression of cellular adhesion molecules, chemokines and pro-inflammatory cytokines critically contributes to vascular inflammation and the initiation and progression of atherosclerosis. By affecting redox-sensitive cell signaling pathways and transcription factors, redox-active transition metal ions, such as copper and iron, may play an important role in these...

Resource Type:

Dissertation
Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

Creator:

Depner, Christopher Michael

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...

Resource Type:

Dissertation

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Academic Affiliation

Chemistry1
Nutrition and Exercise Sciences1
School of Biological and Population Health Sciences1

Advisor

Burrows, Sean M.1
Frei, Balz1
Jump, Donald B.1
Traber, Maret1

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2009 to 2017

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Committee Member

Ho, Emily[remove]4
Backman, Joseph1
Dickenson, Stephen1
Hall, Jean1
Hoffman, Marker1
more Committee Members »

Creator

Barker, Tyler1
Depner, Christopher Michael1
Larkey, Nicholas E.1
Wei, Hao1

Date

Date range begin – Date range end

Current results range from 2009 to 2017

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Decade

2010-20192
2000-20092

Degree Field

Chemistry1
Exercise and Sport Science1
Genetics1
Nutrition1

Degree Level

Doctoral4

Degree Name

Doctor of Philosophy (Ph.D.)4

Language

English [eng]4

License

All rights reserved4

Non-Academic Affiliation

Oregon State University. Graduate School4

Peer Reviewed

No4

Resource Type

Dissertation4

Rights Statement

In Copyright4

Subject

Anterior cruciate ligament -- Wounds and injuries1
Antioxidants1
Atherosclerosis -- Etiology1
Chelation therapy1
Copper in the body1
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