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Filtering by: Creator Yeh, Li-Hsien Remove constraint Creator: Yeh, Li-Hsien Committee Member Ho, Emily Remove constraint Committee Member: Ho, Emily

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  • Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

    Creator:
    Larkey, Nicholas E.
    Abstract:
    One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
    Resource Type:
    Dissertation
    Full Text:
    . Adapted from Li et al. Chem. Soc. Rev. 2014, 43, 506 1.1.1 MicroRNAs as biomarkers Monitoring

  • Activation, incorporation and modification of capreomycidine during viomycin biosynthesis

    Creator:
    Fei, Xiaobo
    Abstract:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
    Resource Type:
    Masters Thesis

  • DHA and Low-fat Low-cholesterol Diets as Treatment Strategies for Nonalcoholic Fatty Liver Disease

    Creator:
    Lytle, Kelli Anne
    Abstract:
    Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess neutral lipids within the parenchymal cells of the liver. The primary etiology is diet-induced and most often exists as a comorbidity with obesity, metabolic syndrome, and/or Type 2 Diabetes. The development of excess liver lipid can be self-limiting...
    Resource Type:
    Dissertation

  • Modulation of metabolic syndrome by soy isoflavones : in-vitro and in-vivo models

    Creator:
    Luo, Ting
    Abstract:
    Metabolic syndrome is a problem affecting people around the world. In a number of studies, soy intake has been documented to possess antidiabetic and anticardiovascular effect. My project is focused on the impact of the intake of compounds found within soy, the isoflavones, their impact on metabolic syndrome symptoms, and...
    Resource Type:
    Dissertation
    Full Text:
    clearance of xenobiotics and impacting bile acid metabolism (Li et al., 2007; Li et al., 2009). Evidence

  • Oxidative stress and muscle dysfunction following anterior cruciate ligament surgery

    Creator:
    Barker, Tyler
    Abstract:
    Despite the advances in surgery, physical therapy, and pharmaceutical agents, muscle dysfunction (i.e., atrophy and weakness) continues to impair recovery from an anterior cruciate ligament (ACL) injury and surgery. Ischemia-reperfusion injury during surgery and the subsequent limb disuse are two events experienced by patients having ACL surgery. Oxidative stress and...
    Resource Type:
    Dissertation
    Full Text:
    ]. Originally, Schulze-Osthoff et al. [322, 323], and subsequently Li et al. [206], found that the activation

  • The role of copper and its chelation by tetrathiomolybdate in inflammation and atherosclerosis

    Creator:
    Wei, Hao
    Abstract:
    Endothelial activation with increased expression of cellular adhesion molecules, chemokines and pro-inflammatory cytokines critically contributes to vascular inflammation and the initiation and progression of atherosclerosis. By affecting redox-sensitive cell signaling pathways and transcription factors, redox-active transition metal ions, such as copper and iron, may play an important role in these...
    Resource Type:
    Dissertation

  • Long-chain (n-3) PUFA and non-alcoholic fatty liver disease

    Creator:
    Depner, Christopher Michael
    Abstract:
    Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...
    Resource Type:
    Dissertation