Index Catalog // ScholarsArchive@OSU

Building a cassette-based system for combined eukaryotic gene expression

Creator:: Madhira, Raviteja
Abstract:: Gene regulatory networks control the state of a cell. Models of such networks have been produced for sea urchin development and suggest that cell type may be defined by distinct network kernels. Such kernels are composed of a set of sequence specific DNA-binding transcription factors (SSTFs) that maintain each other’s...
Resource Type:: Honors College Thesis
Full Text:: for his valuable support in the lab. Finally, I thank Dr. Victor Hsu and Dr. Chrissa Kioussi for

Binding and assembly of H5 (and the globular domain of H5) onto DNA

Creator:: Carter, George John
Abstract:: In order to better characterize linker histone interactions with DNA, avian erythrocyte-specific linker H5 and the trypsin-resistant globular domain of H5 (GH5) were used in DNA binding studies. To begin, H5 displayed a considerably higher binding affinity for DNA than the isolated globular domain (GH5), supporting the importance of the...
Resource Type:: Dissertation
Full Text:: Dr. Victor Hsu, whose excellent advice helped make my thesis an all-around better work. During the

Classification and Analysis of Nucleotide - Nucleotide Interactions in RNA

Creator:: Rouches, Mason
Abstract:: Base-pairing interaction are the fundamental blocks of an RNA structure. With increased ability to determine the structure of RNA molecules, an accurate and informative way of classifying these interactions would help to study RNA structure at many levels. Apart from the well-known complementary base pairs and wobble pairs, other interactions...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Victor Hsu Committee Member, representing the Department of Biochemistry and Biophysics

Bioactive natural products from marine algae

Creator:: Tan, Lik Tong
Abstract:: This thesis is an account of my investigation on the natural products deriving from various marine algae and has resulted in the discovery of thirteen novel bioactive metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D...
Resource Type:: Dissertation
Full Text:: several novel cyclic depsipeptides, given the trivial names clairamides A and B, wewakamide, carliamide

Interaction of linker proteins, H1 and HMG1, with nucleosome reconstituted on positioning sequences

Creator:: An, Woojin
Abstract:: The aim of this research was to gain more understanding on how a linker histone (LH), H1⁰, and high mobility group protein, HMG1, interact with nucleosome. To determine the location of linker proteins, three specific positioning sequences were used to reconstitute core nucleosomes and the binding of H1 and HMG1...
Resource Type:: Dissertation
Full Text:: linker DNA on one side of the core particle. Importantly, the linker DNA site protected b y HMG1 was

Mass spectrometric studies on peptides and proteins : conformations of Escherichia coli Thioredoxin and its alkylated adducts studied by hydrogen/deuterium exchange and HPLC-electrospray ionization mass spectrometry

Creator:: Kim, Moo-young
Abstract:: E. coli thioredoxin (TRX) was modified by the episulfonium ion derived from S-(2-chloroethyl)glutathione (CEG) or S-(2-chloroethyl)cysteine (CEC). The alkylation site was located at Cys-32, which was confirmed by tandem mass spectrometry. Two forms of native TRX, Oxi- and Red-TRX, and two modified TRXs, GS- and Cys-TRX, were examined by hydrogen/deuterium...
Resource Type:: Dissertation
Full Text:: encouragement. I thank my committee members, Dr. Don Reed, Dr. Kevin Gable, Dr. Victor Hsu, Dr. Douglas

Studies on new inorganic solid-state borates and oxoanion flourides

Creator:: Peterson, Gregory A. (Gregory Allen)
Resource Type:: Dissertation
Full Text:: like to extend my appreciation to my PhD committee members: Dr. Carroll DeKock, Dr. Victor Hsu, Dr

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Creator:: Perkins, Arden
Abstract:: Peroxiredoxin (Prx) enzymes catalyze the reduction of hydrogen peroxide, peroxynitrous acid, and organic peroxides, and are extremely efficient peroxidases, with k[subscript cat]/K[subscript M] on the order of 10⁷ - 10⁸ M⁻¹ s⁻¹. Besides their role in oxidative stress defense, evidence has accumulated that some eukaryotes, including humans, use Prxs as...
Resource Type:: Dissertation

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Creator:: Vulpanovici, Florina Alexandra
Abstract:: This thesis details investigations of marine cyanobacterial secondary metabolism, with emphasis on a strain of Phormidium sp. collected in Indonesia. These studies assessed the effects of nineteen putative elicitor compounds on the growth and metabolite production of five species of marine cyanobacteria, biosynthetic investigation of an intriguing secondary metabolite, phormidolide,...
Resource Type:: Dissertation
Full Text:: . Victor Hsu, Dr. Philip Proteau, Dr. Michael Schimerlik and Dr. Goran Jovanovic for their academic

Single-molecule in vitro Characterization of Otoferlin

Creator:: Hams, Nicole J.
Abstract:: Congenital hearing loss is a common disorder and over 60 mutations in the sensory hair cell protein, otoferlin, have been linked to pre-lingual deafness. Although otoferlin is essential for hearing, the large size and low solubility of the protein have limited approaches to study its function on a molecular-level. To...
Resource Type:: Dissertation
Full Text:: members, Dr. Elisar Barbar, Dr. Kate Schilke, Dr. Victor Hsu and Dr. Weihong Qiu, as well as Dr. Ryan

ScholarsArchive@OSU

Building a cassette-based system for combined eukaryotic gene expression

Binding and assembly of H5 (and the globular domain of H5) onto DNA

Classification and Analysis of Nucleotide - Nucleotide Interactions in RNA

Bioactive natural products from marine algae

Interaction of linker proteins, H1 and HMG1, with nucleosome reconstituted on positioning sequences

Mass spectrometric studies on peptides and proteins : conformations of Escherichia coli Thioredoxin and its alkylated adducts studied by hydrogen/deuterium exchange and HPLC-electrospray ionization mass spectrometry

Studies on new inorganic solid-state borates and oxoanion flourides

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Single-molecule in vitro Characterization of Otoferlin

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