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Filtering by: Creator Andre, Jean-Claude Remove constraint Creator: Andre, Jean-Claude Committee Member Karplus, P. Andrew Remove constraint Committee Member: Karplus, P. Andrew Contributor Beckman, Joseph S. Remove constraint Contributor: Beckman, Joseph S.

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  • From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

    Creator:
    Meeuwsen, Joseph C.
    Abstract:
    Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
    Resource Type:
    Dissertation
    Full Text:
    slow death sentence. Jean-Martin Charcot was the first to use the term “amyotrophic lateral