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Filtering by: Creator Sikes, E. Committee Member Karplus, P. Andrew

Protein Disorder in the Evolution of Dynein Regulation

Creator:

Jie, Jing

Abstract:

Intrinsically disordered proteins (IDP) are a class of proteins that lack a three-dimensional structure and their prevalence and diverse functions in the cell have only been discovered relatively recently. The intermediate chain (IC) subunit of the microtubule motor protein complex dynein contains an N-terminal disordered region, N-IC, which is central...

Resource Type:

Dissertation
Characterization of the Structure and Dynamics of the Intrinsically Disordered Dynein Intermediate Chain and its Interactions with Regulatory Binding Partners

Creator:

Morgan, Jessica L.

Abstract:

Cells represent microcosms of spatial and temporal structural organization, with the achievement of internal spatial organization relying upon a collection of macromolecular motor complexes to transport and localize components throughout the cell. Cytoplasmic dynein is one such motor complex, and is the principal ATP-dependent motor for retrograde transport along microtubules...

Resource Type:

Dissertation

Full Text:

………..…….….………………………….....…...…………...……. 38 Rod-ZW10-Zwilch (RZZ) ………..………………........…...…………...……. 43 Nuclear distribution protein E