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Filtering by: Creator Enright, Chris Committee Member Kerkvliet, Nancy Degree Name Doctor of Philosophy (Ph.D.)

Consequences of miRNA misregulation on embryonic development and aging

Creator:

Franzosa, Jill A.

Abstract:

microRNAs (miRNAs), ~21-24 nucleotide-long RNAs that post-transcriptionally regulate gene expression, have rapidly become one of the most extensively studied mechanisms of the past decade. Since their discovery as temporal regulators of post-embryonic development in C. elegans, miRNAs have been functionally implicated in almost every cellular process investigated to date. miRNAs...

Resource Type:

Dissertation

Full Text:

am thankful for Dr. Michael Simonich who helped me with his superb editing skills. Chris Sullivan
Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:

Haggard, Derik

Abstract:

There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...

Resource Type:

Dissertation

Full Text:

conversations and assistance during my later stages in the lab; Chris Sullivan for help and support at the