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Filtering by: DOI 10.1172/JCI62070 Committee Member Kioussi, Chrissa

Regulation of Skeletal Muscle Insulin Action and Fatty Acid Trafficking with Obesity and Exercise

Creator:

Stierwalt, Harrison D.

Abstract:

Altered skeletal muscle fat metabolism is linked to changes in skeletal muscle insulin sensitivity. Whereby the accumulation of bioactive signaling lipids (i.e., diacylglycerols and ceramides) within skeletal muscle are negatively associated with insulin sensitivity and the exercise-induced changes to fatty acid trafficking are related to improved skeletal muscle insulin action....

Resource Type:

Dissertation
Vitamin E Protects Developmental Gene Expression and Metabolic Networks in Zebrafish Embryos

Creator:

Head, Brian A.

Abstract:

Vitamin E (VitE) is necessary for vertebrate embryonic development. VitE prevents lipid peroxidation (LPO), which requires detoxification by cellular antioxidant systems subsequently involving reducing power derived from energy metabolism. Thus, VitE protects metabolic networks in the developing embryo and the integrated gene expression networks compensating for and impaired by LPO-induced...

Resource Type:

Dissertation