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Filtering by: Creator Cox, Jane Remove constraint Creator: Cox, Jane Committee Member Kioussi, Chrissa Remove constraint Committee Member: Kioussi, Chrissa

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  • Vitamin E Protects Developmental Gene Expression and Metabolic Networks in Zebrafish Embryos

    Creator:
    Head, Brian A.
    Abstract:
    Vitamin E (VitE) is necessary for vertebrate embryonic development. VitE prevents lipid peroxidation (LPO), which requires detoxification by cellular antioxidant systems subsequently involving reducing power derived from energy metabolism. Thus, VitE protects metabolic networks in the developing embryo and the integrated gene expression networks compensating for and impaired by LPO-induced...
    Resource Type:
    Dissertation
    Full Text:
    messages, being my library of zebrafish knowledge and being the star that you are. To Jane La Du

  • The role of the transcriptional regulatory protein BCL11B in dental and craniofacial development

    Creator:
    Kyrylkova, Kateryna
    Abstract:
    BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
    Resource Type:
    Dissertation
    Full Text:
    Dr. Jane Ishmael, Dr. Theresa Filtz, Dr. Olena Taratula, Dr. Natalia Shulzhenko, Drs. Gitali and

  • Biosynthesis and Rational Design of Novel Pactamycin Analogs

    Creator:
    Abugrain, Mostafa E.
    Abstract:
    Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
    Resource Type:
    Dissertation
    Full Text:
    , and did the antibacterial assay, as well as cloned and expressed the ptmD gene. Dr. Jane Ishmael did

  • Mass spectrometry techniques to assess the metabolism and toxicity of pharmaceutical and dietary nitrates

    Creator:
    Axton, Elizabeth R.
    Abstract:
    Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
    Resource Type:
    Dissertation
    Full Text:
    feedback. I would like to thank my committee members Robert Tanguay, Susan Tilton, Jane Ishmael, Chrissa