Index Catalog // ScholarsArchive@OSU

Creator:: Axton, Elizabeth R.
Abstract:: Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
Resource Type:: Dissertation
Full Text:: 15N-nitrite. I performed global metabolomics to identify the mechanism of GTN-induced

Creator:: Paraiso, Ines L.
Abstract:: Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...
Resource Type:: Dissertation
Full Text:: chapters, a combination of omics methods including metabolomics, transcriptomics and metagenomics was

Creator:: Gurung, Manoj
Abstract:: Gut microbiota plays an essential role in health and diseases, a fact already established. With the explosive increase in obesity and its main complication, Type 2 Diabetes Mellitus (T2D), there is an immediate need for novel methods of diagnosis, prevention and treatment of these conditions. In the last one and...
Resource Type:: Dissertation
Full Text:: systemic glucose metabolism. We then performed a metabolomics study of serum collected from mono

Creator:: Head, Brian A.
Abstract:: Vitamin E (VitE) is necessary for vertebrate embryonic development. VitE prevents lipid peroxidation (LPO), which requires detoxification by cellular antioxidant systems subsequently involving reducing power derived from energy metabolism. Thus, VitE protects metabolic networks in the developing embryo and the integrated gene expression networks compensating for and impaired by LPO-induced...
Resource Type:: Dissertation
Full Text:: metabolomic analyses I found that E– embryos experience significant disruption to expression of genes

Creator:: Miller, Galen W.
Abstract:: Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...
Resource Type:: Dissertation

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