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Filtering by: Creator Weber, Klaus Committee Member Kioussi, Chrissa

Bcl11b is at the Nexus of Wnt and MAP Kinase Signaling Pathways in Two Stages of Thymocyte Development

Creator:

Selman, Wisam H.

Abstract:

Leukemogenesis, uncontrolled proliferation of dysfunctional, transformed immature lymphocytes, appears, especially in children, to be associated with abrogation of normal lymphopoiesis, and thymopoiesis in the case of T cell leukemias. Sequence specific transcription factors (SSTFs) are nuclear control switches that respond to cellular signals to alter cell state and cell fate...

Resource Type:

Dissertation
Characterization of the Mechanisms of Action and Molecular Targets of Hop-derived Flavonoids in the Mitigation of Obesity-related Metabolic Impairments

Creator:

Paraiso, Ines L.

Abstract:

Obesity is a complex multifactorial disease resulting from excessive energy intake compared to energy expenditure. The excess energy is mostly stored as fat in enlarged adipocytes, but some lipids may infiltrate other organs such as the liver to form ectopic fat. Adipose tissue and ectopic fat produce and secrete a...

Resource Type:

Dissertation

Full Text:

. Keipert, and S. Klaus. 2017. Targeted mitochondrial uncoupling beyond UCP1 – The fine line between death