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Filtering by: Subject Bromomethane -- Toxicity testing Remove constraint Subject: Bromomethane -- Toxicity testing Committee Member Kolluri, Siva Remove constraint Committee Member: Kolluri, Siva Decade 2010-2019 Remove constraint Decade: 2010-2019

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  • Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

    Creator:
    Haggard, Derik
    Abstract:
    There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
    Resource Type:
    Dissertation
    Full Text:
    realize the vision of 21st century toxicity testing. In this dissertation, I employed transcriptomics

  • Developing rapid in vivo assays to investigate structure response relationships

    Creator:
    Truong, Lisa
    Abstract:
    Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
    Resource Type:
    Dissertation
    Full Text:
    second study investigated the different biological responses of three NPs identified during toxicity

  • Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

    Creator:
    Knecht, Andrea L.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
    Resource Type:
    Dissertation
    Full Text:
    pursue testing of neurological effects in a group of OPAHs. From our OPAH developmental toxicity

  • Evaluation of peptide phosphorodiamidate morpholino oligomers as a novel antibiotic therapy

    Creator:
    Kaller, Margo
    Abstract:
    Peptide-phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA mimics that bind and silence gene targets. Through designing PPMOs that silence essential or resistance genes in pathogens, these antisense oligomers could be utilized as novel antimicrobials. Towards this end, my thesis employed minimum inhibitory concentration assays (MICs) to identify PPMOs capable of...
    Resource Type:
    Masters Thesis
    Full Text:
    ........................................................................................................ 34 3.10 Toxicity Testing