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Filtering by: Creator Beaman, Jill A. Remove constraint Creator: Beaman, Jill A. Committee Member Kolluri, Siva Remove constraint Committee Member: Kolluri, Siva

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  • Harnessing Heterogeneity in Human Gut Microbiome Data

    Creator:
    Tataru, Christine
    Abstract:
    The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....
    Resource Type:
    Dissertation
    Full Text:
    charac- terize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets

  • Chemical and biological approaches to identify vertebrate tissue regeneration pathways

    Creator:
    Sengupta, Sumitra
    Abstract:
    Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
    Resource Type:
    Dissertation
    Full Text:
    manuscript. Jill A Franzosa helped with the retinoic acid exposure experiments. In Chapter 2, Dr. Lijoy K

  • Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

    Creator:
    Haggard, Derik
    Abstract:
    There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
    Resource Type:
    Dissertation
    Full Text:
    toxicity information available. Assessing such a large number of chemicals using traditional methods

  • Developing rapid in vivo assays to investigate structure response relationships

    Creator:
    Truong, Lisa
    Abstract:
    Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
    Resource Type:
    Dissertation
    Full Text:
    of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which