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Filtering by: Advisor Goulding, Robert L. Remove constraint Advisor: Goulding, Robert L. Committee Member Kolluri, Siva Remove constraint Committee Member: Kolluri, Siva

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  • Nanoparticle features and their relative influence on biological responses

    Creator:
    Denluck, Lindsay
    Abstract:
    Nanoparticles (NPs), defined as materials having at least one dimension (height, width, diameter) in the nanoscale, are increasingly being incorporated into a wide variety of products and are replacing traditional bulk materials in many applications. This is because they can be more efficacious, more sustainable, and can have unique characteristics...
    Resource Type:
    Dissertation
    Full Text:
    Features and their Relative Influence on Biological Responses Abstract approved: Robert L. Tanguay

  • Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

    Creator:
    Haggard, Derik
    Abstract:
    There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________________ Robert L. Tanguay There are more than 87,000 chemicals in current use with little to no

  • Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

    Creator:
    Knecht, Andrea L.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________________ Robert L. Tanguay Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs

  • Developing rapid in vivo assays to investigate structure response relationships

    Creator:
    Truong, Lisa
    Abstract:
    Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________________ Robert L. Tanguay Incorporation of nanoparticles (NPs) into consumer products is on the rise

  • Chemical and biological approaches to identify vertebrate tissue regeneration pathways

    Creator:
    Sengupta, Sumitra
    Abstract:
    Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
    Resource Type:
    Dissertation
    Full Text:
    Robert L. Tanguay Abstract Numerous human conditions would be improved if therapies to encourage