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Filtering by: Committee Member Cebra, Christopher K. Committee Member Krueger, James H.

Synthesis and oligomerization of y,4-Diamino-2-oxo-1(2H)-pyrimidinepentanoic acid

Creator:

Nelson, Jeffrey Stephen

Abstract:

Described herein is the synthesis of an uncharged stereoregular oligonucleotide analog consisting of cytosine bases linked at specific intervals to a polyamide backbone derived from (L)-glutamic acid. Preparation of this analog entailed borane reduction of (L)- pyroglutamic acid to give optically pure lactam alcohol 9. Tosylation and alkylation with cytosine...

Resource Type:

Masters Thesis

Full Text:

like to thank Dr. Dwight D. Weller for his helpful guidance and enthusiasm, and professors Christopher
Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid

Creator:

Huang, Sung-ben

Resource Type:

Dissertation

Full Text:

also like to thank Dr. Richard W. Thies, Christopher K. Mathews, James H. Krueger, and Austin W
Solid-phase synthesis and biophysical testing of uncharged acyclic oligonucleotide analogues

Creator:

Nelson, Jeffrey Stephen, 1962-

Resource Type:

Dissertation

Full Text:

, Christopher K. Mathews, and Benno P. Warkentin for serving as members of my graduate committee. Brian