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Filtering by: Creator Dye, Paul Committee Member Leid, Mark Creator Myzak, Melinda C.

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:

Myzak, Melinda C.

Abstract:

Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...

Resource Type:

Dissertation