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Filtering by: Subject T cells Remove constraint Subject: T cells Committee Member Leid, Mark Remove constraint Committee Member: Leid, Mark Subject Genetic transcription -- Regulation Remove constraint Subject: Genetic transcription -- Regulation

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  • Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

    Creator:
    Rohlman, Diana
    Abstract:
    The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
    Resource Type:
    Dissertation
    Full Text:
    , may directly influence gene expression during CD4 + T-cell activation and differentiation, thereby