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Filtering by: Creator Michel, Alexa K. Committee Member Leid, Mark Subject Tetrachlorodibenzodioxin -- Toxicology

Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

Creator:

Marshall, Nikki B.

Abstract:

The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...

Resource Type:

Dissertation

Full Text:

Shannon K. Oda Technical support, critical review of manuscript Diana C. Rohlman Technical support
The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:

Funatake, Castle J.

Abstract:

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...

Resource Type:

Dissertation