Index Catalog // ScholarsArchive@OSU

Unraveling tissue regeneration using chemical genetics

Creator:: Mathew, Lijoy K.
Abstract:: The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Lijoy K

Homeodomain Transcription Factor Pitx2 is Required for Muscle Maintenance and Energy Homeostasis

Creator:: Lattier, Vera C.
Abstract:: Skeletal muscle, the largest organ in the body in mass, is composed by 600 specialized muscles in humans with unique biochemical, physiological and metabolic identities. Skeletal muscles control body movement, locomotion, and nutrient balance. Muscle formation requires precisely orchestrated environmental signals and regulatory gene networks in time and space. Gene...
Resource Type:: Dissertation

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:: Bajaj, Gaurav
Abstract:: EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Resource Type:: Dissertation
Full Text:: GST-NR2A (991-1029) or GST-NR1-C0 led to fluorescence quenching of alexa-calmodulin ………………….188

Cellular Recognition, Division, and Proliferation in the Cnidarian-Dinoflagellate Symbiosis

Creator:: Tivey, Trevor R.
Abstract:: Cnidarians and their symbiotic dinoflagellates form a productive mutualism that shapes marine environments. In this symbiosis, dinoflagellate species from the family Symbiodiniacea reside within cnidarian host gastrodermal cells and provide the host with photosynthetically fixed carbon in exchange for host metabolites. This nutritional exchange allows both partners to thrive in...
Resource Type:: Dissertation

Purification and characterization of recombinant calpain-5

Creator:: Wang, Mei-Chuan
Abstract:: Recombinant human calpain-5 was expressed in insect cells using a baculovirus system. The expressed calpain-5 was purified by both traditional chromatography and by affinity-column chromatography. Both methods yielded active protease. Calpain-5 displayed very limited hydrophobicity. This indicated that calpain-5 is not a membrane binding protein. Calpain-5 had pI of 8.3....
Resource Type:: Dissertation

Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

Creator:: Marshall, Nikki B.
Abstract:: The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
Resource Type:: Dissertation
Full Text:: Shannon K. Oda Technical support, critical review of manuscript Diana C. Rohlman Technical support

The role of keratinocytic RXRα in regulating melanocyte homeostasis and carcinogen induced melanomagenesis, The role of keratinocytic RXR[alpha] in regulating melanocyte homeostasis and carcinogen induced melanomagenesis

Creator:: Hyter, Stephen D.
Abstract:: Cutaneous melanoma remains the deadliest form of skin cancer, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. Previous studies determined that mice selectively lacking the nuclear hormone...
Resource Type:: Dissertation
Full Text:: K. Indra Cutaneous melanoma remains the deadliest form of skin cancer, with a diagnosis of

The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

Creator:: Sengupta, Sumitra
Abstract:: Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
Resource Type:: Dissertation
Full Text:: . I will always look up to him as a great source of inspiration. I also want to thank Dr. Lijoy K

ScholarsArchive@OSU

Unraveling tissue regeneration using chemical genetics

Homeodomain Transcription Factor Pitx2 is Required for Muscle Maintenance and Energy Homeostasis

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Cellular Recognition, Division, and Proliferation in the Cnidarian-Dinoflagellate Symbiosis

Purification and characterization of recombinant calpain-5

Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

The role of keratinocytic RXRα in regulating melanocyte homeostasis and carcinogen induced melanomagenesis, The role of keratinocytic RXR[alpha] in regulating melanocyte homeostasis and carcinogen induced melanomagenesis

The influence of aryl hydrocarbon receptor activation on T cell fate

Chemical and biological approaches to identify vertebrate tissue regeneration pathways

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