Index Catalog // ScholarsArchive@OSU

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Creator:: Serrill, Jeffrey D.
Abstract:: Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
Resource Type:: Dissertation
Full Text:: Activity of Select Macrocyclic Natural Products against Glioblastoma Cells Abstract approved: Jane E

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:: Bajaj, Gaurav
Abstract:: EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Resource Type:: Dissertation
Full Text:: Members of the EF-hand Protein Family Abstract approved Jane E. Ishmael EF-hand

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Creator:: Grochowski, Laura L.
Abstract:: Molecular genetic and enzymological techniques have been employed to study secondary metabolite biosynthesis. These investigations have focused on two projects: the cloning and heterologous expression of biosynthetic gene clusters from unculturable marine organisms and the characterization of individual enzymes involved in the biosynthesis of the antifungal agent blasticidin S. The...
Resource Type:: Dissertation
Full Text:: several nucleosidetransferases. bisMwas cloned from the BS gene cluster, heterologously expressed in E

Transcription factor CTIP2 regulates hair follicle development, hair cycling and wound healing

Creator:: Bhattacharya, Shreya
Abstract:: The integumentary system is the largest organ system of the body that comprises of skin and its appendages such as hair follicles, sebaceous and sweat glands. Skin is divided into three distinct structural layers: the epidermis, dermis and hypodermis. The epidermis originates from the ectoderm and is composed of four...
Resource Type:: Dissertation
Full Text:: -/- mice due to the lack of E-cadherin and insufficient expression of alpha smooth muscle actin. Hair

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Creator:: Garcia, Gloria R.
Abstract:: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Resource Type:: Dissertation
Full Text:: E. Peterson Lab from the University of Wisconsin-Madison, Madison, WI, USA. Abraham Garcia

Transcriptional regulation of mouse epidermal permeability barrier development and homeostasis by Ctip2

Creator:: Wang, Zhixing
Abstract:: Skin is the largest organ in the body that protects the organism from environmental, chemical and physical traumas of each passing day. The protective skin epidermal permeability barrier (EPB) is formed within the exterior layers of the epidermis, which are regularly sloughed off and repopulated by movement of inner cells....
Resource Type:: Dissertation
Full Text:: . Candi, E., Schmidt, R., and Melino, G. (2005). The cornified envelope: a model of cell death in the

Impaired epidermal homeostasis in Bcl11bR3S/R3S homozygous mutant mice

Creator:: Kelly, Avalon G.
Abstract:: BCL11B, also known as CTIP2, is a transcription factor which plays a critical role in the regulation and development of many tissues and organ systems, including the skin. A 2019 study by Goos et. al. uncovered a novel point mutation in BCL11B gene that converted the Arginine(R)-3 residue to a...
Resource Type:: Honors College Thesis
Full Text:: : BCL11B, NuRD complex, PRC2 complex, epidermis, epidermal development Corresponding e-mail address

The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation
Full Text:: e activation undergo a period of proliferation and differentiation during which time expression of

Unraveling tissue regeneration using chemical genetics

Creator:: Mathew, Lijoy K.
Abstract:: The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Resource Type:: Dissertation
Full Text:: , Andreasen E, Heideman W and Peterson RE (2000) Identification and expression of alternatively spliced aryl

The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development

Creator:: Shih, Hung Ping
Abstract:: Homeodomain transcription factors control developmental processes. They pattern body formation, specify cell lineages and switch the onset of gene regulatory cascades. Pitx2, a bicoid-related homeodomain transcription factor, is asymmetrically expressed in the left lateral plate mesoderm and mesoderm-derived tissues. Pitx2 null mice are characterized by failure of body wall closure,...
Resource Type:: Dissertation
Full Text:: activate transcription by heterodimerizing with ubiquitously expressed E-proteins to bind a consensus DNA

ScholarsArchive@OSU

Characterization of the Mechanistic Basis for the Cytotoxic Activity of Select Macrocyclic Natural Products against Glioblastoma Cells

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Molecular genetics and enzymology of secondary metabolite biosynthesis. I, Isolation of natural product biosynthesis gene clusters from symbiotic marine organisms. II, Enzymology of blasticidin S biosynthesis

Transcription factor CTIP2 regulates hair follicle development, hair cycling and wound healing

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Transcriptional regulation of mouse epidermal permeability barrier development and homeostasis by Ctip2

Impaired epidermal homeostasis in Bcl11bR3S/R3S homozygous mutant mice

The influence of aryl hydrocarbon receptor activation on T cell fate

Unraveling tissue regeneration using chemical genetics

The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development

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