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Filtering by: Subject Tetrachlorodibenzodioxin -- Toxicology Remove constraint Subject: Tetrachlorodibenzodioxin -- Toxicology Committee Member Leid, Mark Remove constraint Committee Member: Leid, Mark

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  • The influence of aryl hydrocarbon receptor activation on T cell fate

    Creator:
    Funatake, Castle J.
    Abstract:
    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
    Resource Type:
    Dissertation
    Full Text:
    degree of Doctor of Philosophy in Toxicology presented on May 1. 2006. Title: The Influence of Aryl

  • Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

    Creator:
    Marshall, Nikki B.
    Abstract:
    The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
    Resource Type:
    Dissertation

  • Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

    Creator:
    Rohlman, Diana
    Abstract:
    The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
    Resource Type:
    Dissertation
    Full Text:
    for the degree of Doctor of Philosophy in Toxicology presented on May 15, 2013. Title