Index Catalog // ScholarsArchive@OSU

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Creator:: Saili, Katerine Schletz
Abstract:: Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...
Resource Type:: Dissertation
Full Text:: Schletz Saili for the degree of Doctor of Philosophy in Toxicology presented on November 13, 2012

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

Creator:: Rohlman, Diana
Abstract:: The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
Resource Type:: Dissertation
Full Text:: for the degree of Doctor of Philosophy in Toxicology presented on May 15, 2013. Title

The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation
Full Text:: degree of Doctor of Philosophy in Toxicology presented on May 1. 2006. Title: The Influence of Aryl

Unraveling tissue regeneration using chemical genetics

Creator:: Mathew, Lijoy K.
Abstract:: The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Resource Type:: Dissertation
Full Text:: . Mathew for the degree of Doctor of Philosophy in Toxicology presented on October 29, 2007. Title

Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

Creator:: Marshall, Nikki B.
Abstract:: The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
Resource Type:: Dissertation

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Creator:: Garcia, Gloria R.
Abstract:: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Resource Type:: Dissertation
Full Text:: ......................................................................................................... 123 APPENDIX – Advancements in zebrafish applications for 21st century toxicology

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:: Bajaj, Gaurav
Abstract:: EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Resource Type:: Dissertation

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:: Myzak, Melinda C.
Abstract:: Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
Resource Type:: Dissertation

Cellular Recognition, Division, and Proliferation in the Cnidarian-Dinoflagellate Symbiosis

Creator:: Tivey, Trevor R.
Abstract:: Cnidarians and their symbiotic dinoflagellates form a productive mutualism that shapes marine environments. In this symbiosis, dinoflagellate species from the family Symbiodiniacea reside within cnidarian host gastrodermal cells and provide the host with photosynthetically fixed carbon in exchange for host metabolites. This nutritional exchange allows both partners to thrive in...
Resource Type:: Dissertation

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Creator:: Schumann, Canan B.
Abstract:: Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
Resource Type:: Dissertation

ScholarsArchive@OSU

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

The influence of aryl hydrocarbon receptor activation on T cell fate

Unraveling tissue regeneration using chemical genetics

Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Cellular Recognition, Division, and Proliferation in the Cnidarian-Dinoflagellate Symbiosis

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

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